致QT延长药物的研究ppt课件.pptVIP

Jean-Philippe Couderc, PhD, MBA University of Rochester Medical Center Heart Research Follow-Up Program, Cardiology Department Rochester, NY, USA;背 景 I; 目前将体表心电图(ECG)上QT间期延长作为心脏或非心脏性药物的致尖端扭转性室速潜能的一种标志。最近，继非心脏性药物特非那定*及西沙比利**致心源性猝死的几项各案报道后, 美国食品药品管理局(FDA)建议制药公司对所有新药都需测定其潜在的致QT延长作用. (*) Woosley RL, Chen Y, Freiman JP, Gillis RA. Mechanism of the cardiotoxic actions of terfenadine. JAMA 1993 Mar 24;269(12):1532-6. (**) Mohammad S, Zhou Z, Gong Q, January CT. Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride. Am J Physiol 1997 Nov;273(5 Pt 2)