心房颤动的研究现状江洪课件.pptVIP

江 洪 武汉大学人民医院心内科;AF发生机制的再认识：对消融治疗的指导;AF发生机制的经典假说;局灶激动 － 肺静脉Sleeve;肺静脉异常电活动驱动AF;局灶激动 － 分布; 局灶激动的机制 － 1、自律性增加？;;Cheung – J Physiol 314:445, 1980 From distal PV of superfused guinea pig atrium-lung prep (7/17) Approximately 30 bpm, increases in rate with 10-7M norepinephrine Wang et al – Int J of Cardiol 89:187, 2003 Superfused canine PV preparations No examples of spontaneous activity observed (N = 50);No Diastolic Depolarization ;LSPV;PV Rapid Firing;Sunny Po, JACC, 2006;LAO Projection ;Patterson E, Sunny Po, JCE, 2007;LSPV;Action Potential;Sinus Rhythm;EAD;Acetylcholine (10-7M) + Norepinephrine (10-8M) ;Aorta;II;II;aVL;aVL;MR Angiogram - PA Projection;多发子波 折返;AF Begets AF;AF Begets AF的机制－心房重构;心房电重构;Chen PS et al. AJP. 2002;Focal Activity in Chronic Pacing induced AF;Right Thoracotomy;14 dogs;;;;;;Mother Rotors and Fibrillatory Conduction;Electrogram Across the Atria During AF ;II;II; (%);RSPV;Thank you!