多重耐药革兰阴性菌感染治疗图文课件.pptVIP

多重耐药革兰阴性菌感染与治疗;细菌感染性疾病治疗;Antibiotic treatment ;Appropriate therapy Matches antibiotic sensitivities of the organism to the antibiotic used ADEQUATE therapy Choose an appropriate initial antibiotic therapy Use optimal dosing (PD profiling) Select correct route of administration to ensure antibiotic penetration at site of infection Use combination therapy, if necessary;Does Inappropriate Therapy Result From Antibiotic Resistance?;优化抗菌治疗的重要理论依据是药动学/药效学(PK/PD)研究的成果;?-内酰胺类: 优化药物暴露时间;肠杆菌科细菌 临床关注的主要?-内酰胺酶;产ESBLs菌株血行感染死亡率显著增加（Meta分析）;产ESBLs菌株亚胺培南MIC分布;美罗培南和亚胺培南的血浆浓度（1g）;抗菌药物对产ESBLs菌抗菌活性;