微泡介导超声空化对前列腺通透性影响的实验分析-experimental analysis of ultrasound cavitation mediated by microbubbles on prostate permeability.docx

第三军医大学博士学位论文 第三军医大学博士学位论文 PAGE PAGE 10 缩略语表 英文缩写 AC 英文全称 Acoustic cavitation 中文全称 声空化 AI Apoptotic index 凋亡指数 BPB Blood-prostate barrier 血-前列腺屏障 BSA Bovine serum albumin 牛血清白蛋白 DAB Diaminobenzidine 二氨基联苯胺 DAPI 4′,6-diamidino-2-phenylindole, dihydrochloride 4,6 二脒基-2-苯吲哚盐酸 DC Duty cycle 占空比 DIO 3,3′-dioctadecyloxacarbocyanine perchlorate DIO 高氯酸盐 DMSO Dimethyl sulfoxide 二甲基亚砜 d day 天 EB Evans blue 依文思蓝 EBA Endothelial barrier antigen 内皮屏障抗原 Ep Eppendorf 离心机 GFP Green fluorescent protein 绿色荧光蛋白 HE Hematoxylin-eosin 苏木素-伊红 HIFU High intensity focused ultrasound 高强度聚焦超声 HRP Horse radish peroxidase 辣根过氧化物酶 hr hour 小时 IL-2 Interleukin-2 白细胞介素-2 LM Light microscope 光学显微镜 LPS Lipopolysaccharide 脂多糖 LSCM Laser scanning confocal microscopy 激光共聚焦显微镜 MB Microbubble 微泡 MEUS Microbubble enhanced ultrasound 微泡增强超声 min minute 分钟 NIH-CPSI National Institutes of Health, Chronic Prostatitis Symptom Index 国立卫生研究院 - 慢性前 列腺炎症状指数 OD Optical density 光密度 PBS Phosphate buffered saline 磷酸盐缓冲盐水 POD Peroxidase 过氧化物酶 rpm revolutions per minute 每分钟转数 sec second 秒 TdT Terminal deoxynucleotidyl transferase 末端脱氧核苷酸转移酶 TEM Transmission electron microscopy 透射电子显微镜 tPA tissue Plasminogen activator 组织型纤溶酶原激活物 TUNEL Terminal-deoxynucleotidyl transferase mediated nick end labeling 脱氧核糖核苷酸末端转移 酶介导的缺口末端标记法 TUS Therapeutic ultrasound 治疗性超声 UCA Ultrasound contrast agent 超声造影剂 UC Ultrasonic cavitation 超声空化 UMMT Ultrasound-mediated microbubble technique 超声介导微泡技术 US Ultrasound 超声波 UTMD Ultrasound-targeted microbubble destruction 超声靶向微泡破坏 VEGF Vascular endothelial growth factor 血管内皮生长因子 The effect of microbubble mediated ultrasonic cavitation on prostate permeability Abstract Background The prostate is the organ which is prone to male-specific diseases. Common prostate diseases, such as benign prostatic hyperplasia, prostate cancer and prostatitis, seriously affect the survival and quality of life of adult males. At present, the etiology and pathophysiology of these diseases remain poorly understood. I