NT―proBNPH―FABP与cTnI联合检测在老年心力衰竭患者中临床意义.docVIP

NT―proBNPH―FABP与cTnI联合检测在老年心力衰竭患者中临床意义 　　【摘要】 目的：探讨氨基末端B型钠尿肽原（NT-proBNP）、心型脂肪酸结合蛋白（H-FABP）、心肌肌钙蛋白I（cTnI）联合检测在老年心力衰竭（CHF）患者中的临床意义。方法：162例老年CHF患者根据NYHA心功能分级方法分为Ⅰ、Ⅱ、Ⅲ、Ⅳ级，同时选取健康人员50例为对照组，分别检测五组NT-proBNP、H-FABP、cTnI水平，并进行对比分析。结果：对照组与心功能Ⅰ级组cTnI水平比较差异无统计学意义（P0.05），心功能Ⅱ、Ⅲ、Ⅳ级组cTnI水平不断升高，组间比较差异有统计学意义（P0.05）。对照组与各CHF组NT-proBNP、H-FABP水平比较差异有统计学意义（P0.05），随着心功能分级增加NT-proBNP、H-FABP不断升高，组间比较差异有统计学意义（P0.05）。结论：NT-proBNP、H-FABP与cTnI可为疾病的分级提供依据，可作为CHF疗效监测、预后判断及死亡风险评估的客观指标。 　　【关键词】 氨基末端B型钠尿肽原； 心型脂肪酸结合蛋白； 心肌肌钙蛋白Ⅰ； 心力衰竭 　　doi：10.14033/j.cnki.cfmr.2017.3.003 文献标识码 A 文章编号 1674-6805（2017）03-0008-02 　　【Abstract】 Objective：To discuss the clinical significance of determination of NT-proBNP，H-FABP and cTnI in elderly patients with chronic heart failure（CHF）.Method：162 elderly patients with CHF were divided into grade Ⅰ，grade Ⅱ，grade Ⅲ，grade Ⅳ according to the NYHA cardiac function classification method，and 50 healthy people were considered as the control group，then NT-proBNP， H-FABP and cTnI were detected and contrasted in the people of the five groups.Result：There was no significantly difference in cTnI between the control group and grade Ⅰgroup（P0.05），but sustainedly increased in grade Ⅱ，grade Ⅲ，and grade Ⅳgroup（P0.05），and all significantly higher than the control group（P0.05）.There was significant differerce between control group and heart function classification groups on level of NT-proBNP and H-FABP（P0.05），and level of NT-proBNP and H-FABP sustainedly increased with heart function classification increasing（P0.05）.Conclusion：NT-proBNP，H-FABP and cTnI can provide basis for disease classification，all of which are objective indexes for efficacy monitoring，prognosis judging and mortality risk evaluating in elderly patients with CHF. 　　【Key words】 NT-proBNP； H-FABP； cTnI； Chronic heart failure 　　First-author’s address：Traditional Chinese Medicine Hospital of Pi County，Pi County 611730，China 　　慢性心力衰竭（chronic heart failure，CHF）具有?^高的发病率与死亡率，是各种原因导致的心脏病的终末期，较难与呼吸系统疾病导致的呼吸困难区分。对CHF做出快速诊断，对降