N―端B型钠利尿肽与心力衰竭关系研究.docVIP

N―端B型钠利尿肽与心力衰竭关系研究 　　摘要：目的 研究N-端B型钠利尿肽（BNP）和心力衰竭的关系。方法 随机选取我院收取的确诊为心力衰竭的患者80例（其中心肌病22例，高血压心脏病29例，冠心病25例，风心病4例），根据NYHA分级心功能I级10例，II级21例，III级26例，IV13例。对所有患者均进行NT-BNP检测，以及左室射血分数（LVEF）、左室舒张内径（LEVDD）、血脂和肾功能检查。根据患者BNP浓度水平分为A组和B组，其中A组NT-BNP浓度400pg/ml，B组NT-BNP浓度≥400pg/ml，并比较两组患者不同指标变化。结果 随着NT-BNP浓度增加，心功能NHYA等级越高，且LEVDD增大，LEVF、胆固醇以及低密度脂蛋白验降低，尿素氮、肌酐增高。两组数据差异显著，均具有统计学意义（P0.05）。结论 NT-BNP水平能够准确的反应心力衰竭的严重程度和患者左室功能，可以作为诊断、病情评估和预测预后心力衰竭的一个重要指标。 　　关键词：N-端B型钠利尿肽；心力衰竭；关系研究 　　Abstract：Objective To research the relationship between NT-proBNP and heart failure.Methods 80 patients with heart failure（22 cases of cardiomyopathy，29 cases of hypertensive heart disease，25 cases of coronary heart disease，4 cases of rheumatic heart disease），were randomly selected，according to NYHA grade，grade I 10，grade II 21，grade，grade III 26，grade IV 13 patients.NT-BNP was performed for all patients，and left ventricular ejection fraction（LVEF），left ventricular diastolic diameter，blood lipid and renal function were examined.According to NT-BNP concentration levels were divided into group A and group B，of which a group of NT-BNP concentration400pg/ml.B group NT-BNP concentration is more than or equal to 400pg/ml and compare the two group of patients with different index changes.Results With the increase of NT-BNP concentration，the higher cardiac function NHYA levels，and the end diastolic diameter of left ventricular end diastolic，LEVF，cholesterol and low density lipoprotein cholesterol test，urea nitrogen，creatinine increased.The difference between the two groups was statistically significant（P0.05）.Conclusion NT-proBNP precursor concentration can accurately respond to the severity of heart failure and left ventricular function，and can be used as an important index for diagnosis，prognosis and prognosis of heart failure. 　　Key words：NT proBNP；Heart failure；Relationship research 　　有研究资料表明，BNP前体水平和心力衰竭具有相关性[1-2]。为了研究NT-BNP浓度和心力衰竭的关系，随机选取80例心衰患者并进行NHYA分级，根据检查出的BNP水平进行分组，并对照二者LEVDD、LEVF、胆固醇、低密度脂蛋白、尿素氮、肌酐等指标变化，现