HcyBNP检测在2型糖尿病肾病早期诊断中价值分析.docVIP

HcyBNP检测在2型糖尿病肾病早期诊断中价值分析 　　摘 要：目的 分析Hcy和BNP联合检测在2型糖尿病肾病早期诊断中的价值。方法 选取2015年6月～2017年6月我院收治的2型糖尿病患者60例作为研究对象，依据尿蛋白排泄率分为A组（n=20，正常蛋白尿组）、B组（n=20，微量蛋白尿组）、C组（n=20，临床蛋白尿组），选择健康体检者20例作为对照组，对四组血浆Hcy、BNP及Cys-C、UmALB、Scr进行检测，并对检测结果进行比较。结果 UmALB无论被定性为阴性或阳性，A、B、C 三组的Hcy、BNP、Cys-C、Scr均显著高于对照组，差异有统计学意义（P0.05）；UmALB被定性为阳性时，B组、C组的Hcy、BNP、Cys-C、Scr高于A组，组间比较，C组高于B组，差异有统计学意义（P0.05）。结论 Hcy和BNP与UmALB均存在密切关系，二者联合检测具有较高的诊断准确率，可对2型糖尿病肾病的损害程度进行推断，具有较高的早期诊断价值。 　　关键词：2型糖尿病肾病；BNP；Hcy；早期诊断 　　中图分类号：R714.22 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.03.060 　　文章编号：1006-1959（2018）03-0163-02 　　Abstract：Objective To analyze the value of combined detection of Hcy and BNP in the early diagnosis of type 2 diabetic nephropathy.Methods 60 patients with type 2 diabetes mellitus admitted to our hospital from June 2015 to June 2017 were divided into group A（n=20，normal proteinuria group）and group B（n=20，microalbuminuria group），C group（n=20，clinical proteinuria group），20 healthy subjects were selected as the control group，plasma Hcy，BNP and Cys-C，UmALB and Scr were detected in the four groups.The test results were compared.Results Whether UmALB was negative or positive，the levels of Hcy， BNP， Cys-C and Scr in group A，B and C were significantly higher than those in control group（P0.05）；When UmALB was positive， the levels of Hcy，BNP，Cys-C and Scr in group B and group C were higher than those in group A，compared between groups，C group was higher than B group，the difference was statistically significant（P0.05）.Conclusion Hcy and BNP are closely related to UmALB.The combined detection of Hcy and BNP has high diagnostic accuracy，which can be used to infer the degree of damage of type 2 diabetic nephropathy，which has high diagnostic value in early stage. 　　Key words：Type 2 diabetic nephropathy；BNP；Hcy；Early diagnosis 　　糖尿病肾病（diabetic nephropathy）是糖尿病患者较为常见的一种并发症，?儆谏鲂∏虿”洌?显著性特征为微血管损害，一旦出现持续不断的大量蛋白尿，患者病情亦会进入难以逆转的阶段，最终向肾功能衰竭发展，导致患者死亡。到目前为止，临床方面尚未明确该病的发病机制。以往临床主要通过检测血清尿素氮（BUN）、尿微量白蛋白（UmALB）、血肌酐（Scr）及肌酐清除率等对肾功能异常与否