HER2βcatenin及Ki67在胃癌中表达及其临床意义.docVIP

HER2βcatenin及Ki67在胃癌中表达及其临床意义 　　摘要：目的 探讨胃癌组织中人表皮生长因子受体-2（HER-2），β-catenin和Ki-67的表达及与临床病理特征的关系。方法 应用免疫组化SP法检测90例胃癌组织中HER-2、β-catenin及Ki-67表达情况，并结合临床病理特征进行分析。结果 HER-2在胃癌组织中的阳性表达率为37.8%，β-catenin为65.6%，Ki-67为55.6%。HER-2、β-catenin及Ki-67在胃癌中的阳性表达与肿瘤分化程度、浸润深度、淋巴结转移及TNM分期有关（P0.05）。HER-2、β-catenin及Ki-67三者之间在胃癌中的表达均呈正相关（P0.01）。结论 HER-2、β-catenin及Ki-67参与胃癌的生长、侵袭和转移过程，联合检测有助于胃癌患者靶向药物治疗的初筛及对患者的预后评价。 　　关键词：胃癌；HER-2；β-catenin；Ki-67；免疫组织化学 　　Expressions and clinical significance of HER-2，β-catenin and Ki-67 in gastric cancer 　　QUAN Xi-yun1， LI Ming2 　　（1. Zhuzhou Central Hospital of Hunan， Hunan， Zhuzhou 412000， China； 2. The Affiliated Xiang-dong Hospital of Hunan Normal University， Hunan， Liling 412200， China） 　　Abstract： Objective To investigate the expressions of HER-2，β-catenin and Ki-67 in human gastric carcinoma and to study the relationship among them and the clinicopathological factors of gastric carcinoma. Methods The SP immunohistochemical stain method was used to detect HER-2，β-catenin and Ki-67 protein expressions in 90 samples of gastric carcinoma tissues. And clinical data were analyzed retrospectively. Results Positive rate of HER2 was 37.8%，β-catenin was 65.6 % and Ki-67 was 55.6% in gastric carcinoma. The positive expression rates of HER-2，β-catenin and Ki-67 protein in gastric carcinoma tissues were closely related to the differentiation of the carcinoma，invasion depth，lymphatic metastasis and TNM（ P 0.05） .There was a stable positive correlation among HER-2，β-catenin and Ki-67 expressions in gastric carcinoma tissues（ P0.01）. Conclusion HER-2，β-catenin and Ki-67 participate the development，invasion and metastasis process of gastric carcinoma. Joint detection of them can be looked as a primary detection for guiding the molecular targeting therapy of gastric carcinoma，and judging the prognosis of gastric carcinoma and providing basis for gene detection. 　　Key words： gastric carcinoma； HER-2；β-catenin ； Ki-67； immunohistochemistry 　　胃癌是严重危害人类健康的最常见恶性肿瘤之一，