EGFR和VEGF在三阴乳腺癌中表达及意义.docVIP

EGFR和VEGF在三阴乳腺癌中表达及意义 　　【摘要】 目的:研究三阴乳腺癌中EGFR与VEGF的表达及意义,并探讨其与临床病理参数之间的关系。方法:应用免疫组化MaxVision法检测45例三阴乳腺癌中EGFR与VEGF的表达,并分析它们与三阴乳腺癌患者的年龄、肿瘤大小、病理类型、淋巴结转移及p53、E-cad的关系。结果:EGFR和VEGF在三阴乳腺癌组的表达显著高于非三阴乳腺癌组(P0.05);但在有淋巴结转移及E-cad阴性的三阴乳腺癌中EGFR的阳性表达率显著高于相应对照组(P0.05);但在淋巴结转移、p53分组间的表达上差异有统计学意义(P0.05)。结论:EGFR、VEGF在TNBC中过表达,有可能成为TNBC分子靶向治疗的新靶点和突破口;联合检测EGFR、VEGF、E-cad及p53的表达,对判断TNBC的复发转移及预后有一定的意义,是综合评价TNBC的重要标志物。 　　【关键词】 三阴乳腺癌; 表皮生长因子受体; 血管内皮生长因子 　　The Expression and Significance of EGFR and VEGF in Triple Negative Breast Cancer/SU Shu-juan.// Medical Innovation of China,2012,9(33):008-010 　　【Abstract】 Objective:To research the expression and significance of EGFR and VEGF in triple negative breast cancer,exploring the relationship between clinicopathological parameters.Method:Immunohistochemistry MaxVision was used to detect the expression of EGFR and VEGF in triple negative breast cancer,moreover,the relationship between EGFR ,VEGF and triple negative breast cancer patients age, tumor size, histological type , lymph node metastasis, and p53 , E - cad were analyzed.Result:The expression of EGFR and VEGF in triple negative breast cancer group was significantly higher than the non - triple negative breast cancer group(P0.05);however,the expression of EGFR in lymph node metastasis and E-cad - negative group was significantly higher than the corresponding control group(P0.05);however,the expression of VEGF in lymph node metastasis and p53 - positive group was significantly higher than the corresponding control group(P0.05).Conclusion:The overexpression of EGFR and VEGF in TNBC may be a new target and a breakthrough of molecular targeted therapy;the expression of EGFR、VEGF、E-cad and p53,is a certain sense of judgment TNBC recurrence and metastasis and prognosis,and an important marker of comprehensive evaluation of TNBC. 　　【Key words】 TNBC; EGFR; VEGF 　　First-author’s address: The First Affiliated Hospital of Nanyang Medical College ,Nanyang 473000,China 　　doi:10.3969/j.issn.1674-4985.2