胰岛素治疗患者体重管理.pptVIP

* * * * * * * Background information The schematic diagram is based on hypotheses proposed in the following references: Hallschmid et al. Diabetes 2010;50(4):1101–7 Hendriksen et al. Diabetologia 2010;53(Suppl. 1):S23 (A-41) Zachariah et al. Diabetologia 2010;53(Suppl. 1):S391 (A-981) Banks. Eur J Pharmacology 2004;490:5–12 Schwartz Porte. Science 2005;307:375–9 Hennige et al. Diabetologia 2006;49(6):1274–82 Tschritter et al. PLoS One 2007;2:e1196 一项随机对照交叉研究对比了地特胰岛素和NPH治疗后食欲相关大脑区域的脑血流量和葡萄糖代谢状况。该项研究总共成功入组了28名T1DM患者，经过四周的导入期后，被随机分配到地特胰岛素或者NPH组，都同时联合使用门冬胰岛素，进行为期12周的治疗，其中每周进行一次7点SMBG监测，并通过电话