农村血尿酸水平对冠心病影响临床研究.docVIP

农村血尿酸水平对冠心病影响临床研究 　　[摘要] 目的 研究农村血尿酸水平对冠心病影响和意义。 方法 按是否患有冠心病这一分组标准从2013年12月～2015年12月农村冠心病患者中随机选取72例为观察组，农村健康体检群体中随机选取72例为对照组作为研究对象。比较两组基本临床资料，观察患者血尿酸水平与冠心病之间的联系。并对冠心病患者实施别嘌呤醇进行治疗，观察治疗后对患者冠心病影响情况。 结果 男性患者体内血尿酸含量显著高于女性，且年龄越大，血尿酸含量越高，差异均有统计学意义（均P0.05）。观察组ABI水平显著低于对照组，治疗后两组无明显差异（P0.05）。 结论 冠心病发病率与农村血尿酸水平呈正相关，高水平血尿酸参与冠心病的发生与发展。临床将血尿酸水平作为治疗的一项，对冠心病的防治具有重要意义。 　　[关键词] 血尿酸；冠心病；嘌呤醇；ABI 　　[中图分类号] R541.4 [文献标识码] B [文章编号] 2095-0616（2016）09-198-04 　　[Abstract] Objective To explore the effect and significance of blood uric acid on coronary heart disease in rural area. Methods 72 patients with coronary heart disease in rural area during December 2013 and December 2015 were randomly selected as observation group， and another 72 healthy individuals in rural area were selected as control group. The basic clinical data of the two groups were studied and compared， the relationship between blood uric acid and coronary heart disease was analyzed. The coronary heart disease patients were treated with allopurinol， which curative effect was analyzed. Results The blood uric acid levels of male patients were obviously higher than those of female patients， and the blood uric acid level had a positive correlation with patients age， the differences were statistically significant （P0.05）. Conclusion There is a positive correlation between incidence of coronary heart disease and blood uric acid levels of patients in rural area， high blood uric acid level evokes and promotes the coronary heart disease. Controlling blood uric acid level in clinical practice is very important for the prevention and treatment of coronary heart disease. 　　[Key words] Blood uric acid； Coronary heart disease； Allopurinol； ABI 　　通常而言，高尿酸血症多半和高血脂、高血压及2型糖尿病等心血管疾病一起发生。当前临床上对血尿酸水平和心血管疾病之间的关联存在较大争议，大部分学者认为，心血管疾病发生率与血尿酸水平呈正相关，而高尿酸血症发生率于不同地区、不同种族间也存在较大的区别[1]。据资料显示[2]，沿海地区的高尿酸血症发生率显著高于其他地区，然而农村地区发生情况仍不清楚。而近几年农村冠心病发生率呈逐渐上升趋势，且呈年轻化的趋势，严重影响人们生活质量，危及生命健康。鉴于此，本研究对农村冠心病患者的血尿酸水平进行分析，旨在分析两者之间的关系，并采取嘌呤醇进行治疗，得到一些结论，现报道如下。 　　1 资料与方法