内蒙古高氟地区血清维生素D和2型糖尿病相关性探讨.docVIP

内蒙古高氟地区血清维生素D和2型糖尿病相关性探讨 　　[摘要] 目的：探讨内蒙古高氟地区血清维生素D含量和2型糖尿病的关系，为临床合理防治2型糖尿病提供依据。方法：本研究均选择本地居住10年以上居民，其中2型糖尿病75例，对患者的血清25羟基维生素D[25（OH）D3]含量、血清钙磷、血糖（BG）、糖化血红蛋白（HbA1c）、胰岛素、C肽、血脂谱、体重指数（BMI）、胰岛素抵抗指数和β细胞功能指数（HOMAβc）等指标进行综合分析，同时选取51例健康人的血清25（OH）D3含量作为对照。结果：2型糖尿病组与健康对照组的25（OH）D3水平比较，差异有高度统计学意义（P0.01），分别为（2.87±2.83）、（14.38±14.01）nmol/L，两者均明显低于其他地区和国家最低标准（50 nmol/L）；血清25（OH）D3水平和HbA1c、BMI和空腹血糖（FBG）呈负相关（r=-0.240、-0.231、-0.392，均P0.05）；血清25（OH）D3水平和HOMAβc呈正相关（r=0.274，P0.05）。结论：内蒙古高氟地区维生素D水平较其他地区和国家明显降低；维生素D水平和2型糖尿病的发病和病情严重程度有关。给予本地区居民补充维生素D，一方面可以减少高氟损害，另一方面可以延缓2型糖尿病的病情。 　　[关键词] 高氟地区；25羟基维生素D；2型糖尿病 　　[中图分类号] R587.1 [文献标识码] Ａ [文章编号] 1673-7210（2011）12（b）-054-03 　　 　　Relationship between vitamin D levels and type 2 diabetes mellitus in the endemic fluorosis area of Inner Mongolia Autonomous Region 　　ZHANG Yijing, LU Ying, TIAN Hengwen, ZHANG Shuying, GUAN Xiujing, LI Conglong 　　Department of Endocrinology, the Eighth Hospital of Baotou City, Inner Mongolia Autonomous Region, Baotou 014040, China 　　[Abstract] Objective: To determine the relationship between vitamin D levels and type 2 diabetes mellitus in the endemic fluorosis area of Inner Mongolia Autonomous Region, and to provide evidence of reasonable prevention and treatment method to type 2 diabetes patients in clinic. Methods: All of the groups had lived in the local region above ten years. Serum 25-hydroxyvitamin D, calcium and phosphorus, fasting blood glucose, HbA1c, body mass index (BMI), serum lipid profile, fasting blood insulin, insulin resistant index (HOMAIR) and β-cell function (HOMAβ-cell) were analyzed in 75 patients with type 2 diabetes, and serum 25-hydroxyvitamin D was detected in 51 healthy adults who were assessed as control group. Results: Mean(SD) 25-hydroxyvitamin D levels of type 2 diabetes group and health control group were (2.87±2.83) nmol/L and (14.38±14.01) nmol/L respectively, and there was a significant difference between them (P0.01), which noticeably decreased than lowest normal of the oth