前列康片联合头孢呋辛酯片对慢性前列腺炎患者血清细胞因子影响及疗效分析.docVIP

前列康片联合头孢呋辛酯片对慢性前列腺炎患者血清细胞因子影响及疗效分析 　　[摘要] 目的 探?前列康片联合头孢呋辛酯片对慢性前列腺炎患者血清细胞因子的影响及疗效。 方法 选择我院2013年1月～2015年12月接诊的148例慢性前列腺炎患者，随机分成两组，观察组74例患者给予前列康片联合头孢呋辛酯片治疗，对照组74例患者给予头孢呋辛酯片治疗，通过比较两组患者临床症状改善、中医症候及前列腺液中分泌型免疫球蛋白A（SIgA）、血管细胞粘附分子-1（VCAM-1）及血清VCAM-1变化，讨论前列康片联合头孢呋辛酯片对慢性前列腺炎患者血清细胞因子的影响及疗效。 结果 观察组临床疗效总有效率94.59%，高于对照组临床疗效总有效率78.38%，两组比较差异有统计学意义（P0.05）。两组治疗前NIH-CPSI指数没有明显差异，两组治疗后NIH-CPSI指数均有显著改善，观察组的改善更优于对照组，两组比较差异有统计学意义（P0.05）。两组治疗前中医证候积分没有明显区别，治疗后均有所减少，观察组的减少大于对照组（t=3.0447，P=0.0033）。观察组中医证候疗效总有效率91.89%，高于对照组中医证候疗效总有效率72.97%，差异有统计学意义（P0.05）。两组治疗前前列腺液中SIgA、VCAM-1及血清VCAM-1均无明显差异，治疗后均有降低，观察组的改善更优于对照组，两组比较差异有统计学意义（P0.05）。 结论 前列康片联合头孢呋辛酯片的治疗方法，能有效调节血清细胞因子控制炎症，对慢性前列腺炎治疗起到较好效果，值得临床应用。 　　[关键词] 前列康片；头孢呋辛酯片；慢性前列腺炎；血清细胞因子 　　[中图分类号] R697.3 [文献标识码] A [文章编号] 1673-9701（2017）14-0028-04 　　[Abstract] Objective To investigate the influence and therapeutic effect of Qianliekang tablets combined with cefuroxime axetil tablets on serum cytokines in patients with chronic prostatitis. Methods 148 patients with chronic prostatitis who were admitted to our hospital from January 2013 to December 2015 were selected and randomly divided into two groups. The patients（n=74） in the observation group were treated with Qianliekang tablets combined with cefuroxime axetil tablets and 74 patients in the control group were treated with cefuroxime axetil tablets.The influence and therapeutic effect of Qianliekang tablets combined with cefuroxime axetil tablets on serum cytokines in patients with chronic prostatitis were explored by comparing the clinical symptoms improvement， Chinese medicine symptoms and the changes of secretory immunoglobulin A （SIgA），vascular cell adhesion molecule-1 （VCAM-1） and serum VCAM-1 between the two groups. Results The clinical total effective rate was 94.59% in the observation group， higher than 78.38% of the control group. The difference was statistically significant（P 　　[Key words] Qianliekang tablets； Cefuroxime axetil tablets； Chronic prostatitis； Serum cytokines 　　慢性前列腺炎是泌尿生殖