反复呼吸道感染患儿血清微量元素及免疫指标测定与分析.docVIP

反复呼吸道感染患儿血清微量元素及免疫指标测定与分析 　　[摘要] 目的：探讨血清锌、铜、钙、镁水平与反复呼吸道感染患儿免疫指标的关系。方法：用原子吸收法对77例反复呼吸道感染患儿进行血清锌、铜、钙、镁水平与免疫指标测定，并分析反复呼吸道感染患儿锌、铜、钙缺乏与免疫功能的关系。结果：反复呼吸道感染患儿血清锌、铜、钙均较低，与正常对照组比较，有非常显著性差异（P0.01）；血清镁正常，大部分患儿免疫指标水平降低，但低锌患儿免疫指标水平降低更显著。结论：反复呼吸道感染患儿存在微量元素锌、铜、钙缺乏，其中低锌也是造成免疫指标低下的原因之一，提示临床医师应对反复呼吸道感染患儿常规检测微量元素，尤其是锌，并及时补充。 　　[关键词] 反复呼吸道感染；免疫指标；微量元素 　　[中图分类号] R56[文献标识码]A [文章编号]1673-7210（2009）06（c）-011-02 　　 　　Determination and analysis of serum trace elements and immune indexes of children with recurrent respiratory infection 　　PANG Yin 　　(Department of Pediatrics, the First Peoples Hospital of Jining City, Shangdong Province, Jining 272011, China) 　　[Abstract] Objective: To investigate the relationship between serum Zn, Cu, Ca, Mg and immune indexes of Children with recurrent respiratory infection (RRI). Methods: The level of serum Zn, Cu, Ca and Mg in 77 children with RRI were measured by atomic absorption spectrophotometry. Meanwhile, the relationship between deficiency of serum Zn, Cu, Ca and immune indexes of children with RRI was analyzed. Results: The level of serum Zn, Cu and Ca in children with RRI was significantly lower than that of normal control group (P0.01). The level of serum Mg in children with RRI was normal. The majority of children with RRI were prone to lower immune function, especially who had lower serum Zn. Conclusion: Children with RRI have lower trace elements of Zn, Cu and Ca. Insufficiency of Zn could result in immune function. The trace elements should be measured routinely in children with RRI, the appropriate content needs to be supplemented if the trace elements are low. 　　[Key words] Recurrent respiratory infection; Immune indexes; Trace elements 　　 　　儿童反复呼吸道感染（RRI）是儿科呼吸系统常见疾病，与小儿因营养状况、环境污染、气候变化等因素造成的机体免疫功能状态异常密切相关，其中微量元素的缺乏与其相关性日益受到重视。为了探讨微量元素及矿物质与RRI患儿的关系，笔者2007年1月~2008年2月对77例RRI患者进行了血清锌、铜、钙、镁水平与免疫指标测定，细致地探讨了锌缺乏与RRI患儿免疫功能状态异常的关系，现报道如下： 　　1 资料与方法 　　1.1 一般资料 　　观察组77例均为就诊于我科门诊或住院患儿，按1987年4月全国呼吸道成都会议制定的诊断标准[1]确诊为RRI；正常对照组69例，为儿童保健门诊经全面体格检查