双相抑郁障碍与单相抑郁症患者促甲状腺激素相关性研究.docVIP

双相抑郁障碍与单相抑郁症患者促甲状腺激素相关性研究 　　[摘要] 目的 探讨双相抑郁障碍与单相抑郁症患者的促甲状腺激素的相关性。方法 选取我院2015年1月～2016年6月收治的抑郁症患者37例，按照患者病情不同分为单相组（19例）和双相组（18例），选取同期进行体检后的健康人群18例作为对照组，检测三组患者的T3、T4、TSH等指标，并行HAMD量表评分。结果 治疗前双相组、单相组患者T3水平为（2.05±0.63）nmol/L、（2.01±0.36）nmol/L，高于对照组的（1.65±0.65）nmol/L，差异显著（P0.05）。治疗后单相组和?p相组T4水平与对照组相比，差异显著（P0.05）；治疗后单相组评分为（4.75±0.51）分，优于双相组的（6.65±0.55）分，差异有统计学意义（P0.05）。结论 大多数抑郁症患者的甲状腺激素水平存在异常，治疗后单相抑郁障碍的患者临床症状改善较双相抑郁障碍明显，激素水平得到改善，提示单相抑郁障碍的发生主要与其激素水平变化有密切关系，与双相抑郁障碍关系尚不明确。 　　[关键词] 双相抑郁障碍；单相抑郁障碍；抑郁症；促甲状腺激素 　　[中图分类号] R749.4 [文献标识码] B [文章编号] 1673-9701（2017）07-0088-04 　　[Abstract] Objective To investigate the correlation of thyrotropin between bipolar depression and monopolar depression. Methods 37 patients with depression who were admitted to our hospital from January 2015 to June 2016 were selected. According to different conditions， the patients were divided into monopolar group （19 cases） and bipolar group （18 cases）. 18 healthy people who were given physical examination during the same period were selected as the control group. T3， T4， TSH and other indices were tested in the three groups and the score of HAMD scale was calculated. Results The level of T3 in the bipolar group and the monopolar group before the treatment was（2.05±0.63） nmol/L and（2.01±0.36） nmol/L， which was higher than that in the control group （1.65±0.65） nmol/L， and the difference was significant（P0.05）. The T4 level in the the bipolar and monopolar groups was significantly different from that in the control group， and the difference was significant （P0.05）； after the treatment， the score in the monopolar group was （4.75 ± 0.51） points， which was better than（6.65±0.55） in the bipolar group， and the difference was statistically significant（P0.05）. Conclusion Most patients with depression have abnormal thyrotropin level. After the treatment， the improvement of clinical symptoms in the patients with monopolar depression are more significant the patients with bipolar depression， and the hormone level is imp