地西他滨联合CAG方案治疗老年急性髓系白血病效果和安全性分析.docVIP

地西他滨联合CAG方案治疗老年急性髓系白血病效果和安全性分析 　　【摘要】 目的：探究老年急性髓系白血病采用地西他滨联合CAG方案治疗的临床效果与安全性。方法：选取笔者所在医院2015年2月-2017年2月收治的56例老年急性虽髓系白血病患者，并采用抽签的方式将其分为两组，对照组28例患者采用CAG方案治疗，观察组28例患者采用地西他滨联合CAG方案联合治疗，并对两组患者的治疗效果与不良反应情况进行对比。结果：观察组患者治疗总有效率为77.57%，高于对照组患者的50.00%，差异有统计学意义（字2=4.98，P0.05）；观察组患者肺部感染、恶心呕吐及发热发生率均低于对照组，差异均有统计学意义（P0.05）。结论：老年急性髓系白血病采用地西他滨联合CAG方案治疗的临床效果显著，安全性较好。 　　【关键词】 地西他滨； CAG方案； 老年急性髓系白血病； 疗效； 安全性 　　doi：10.14033/j.cnki.cfmr.2018.1.004 文献标识码 A 文章编号 1674-6805（2018）01-0008-02 　　The Efficacy and Safety Analysis of Decitabine Combined with CAG Regimen in Treatment of Senile Acute Myeloid Leukemia /CHEN Xiaomin.//Chinese and Foreign Medical Research，2018，16（1）：8-9 　　【Abstract】 Objective：To investigate the efficacy and safety of Decitabine combined with CAG regimen in treatment of senile acute myeloid leukemia.Method：Fifty-six elderly patients with myeloid leukemia who were treated in the author’s hospital from February 2015 to February 2017 were selected and divided into two groups by means of lottery.The control group（28 patients） was treated with CAG regimen，the observation group（28 patients） was treated with Decitabine combined with CAG regimen，the therapeutic effects and adverse reactions of two groups were compared.Result：The total effective rate was 77.57% in the observation group，and higher than 50.00% in the control group，the difference was statistically significant （字2=4.98，P0.05）.The incidence of pulmonary infection，nausea，vomiting and fever in the observation group were lower than those in the control group， the differences were statistically significant （P0.05）.Conclusion：The effect of Diclofenac and CAG regimen in treatment of senile acute myeloid leukemia with is obvious and safe. 　　【Key words】 Decitabine； CAG regimen； Senile acute myeloid leukemia； Efficacy； Safety 　　First-author’s address：Changshu Hospital Affiliated to Suzhou University，Changshu 215500，China 　　急性髓系白血病是一?N恶性克隆性疾病，按照相关资料显示，伴随我国人口老龄化问题的严重，此病的发病率呈上升的发展趋势[1]。并且因为老年患者自身身体功能下降，接受化疗治疗后的耐受能力较弱，所以化疗