没食子酸于四级铵盐化几丁聚醣之生物相容性-亚东技术学院.PDF

沒食子酸於四級銨鹽化幾丁聚醣之生物相容性 周啟雄 ＊ 、陳信銘、邱建智、王煒傑、徐辜慶、蔡榕維、王儀明 亞東技術學院材料與纖維系 E-mail: fc015@mail.oit.edu.tw ABSTRACT: In this research, the polycationic chitosan 衍生物。藉由金黃色葡萄球菌及 L929 纖維母細胞增生實驗 derivates HMDC-GA were synthesized by gallic acid with 來評估 HMDC-GA的抗菌性及細胞相容性，期盼含多酚結 N-(2-hydroxyl) propyl-3-methyl diallyl quaternary ammonium 構的四級銨鹽化幾丁聚醣衍生物能兼具抗氧化活性、抗菌性 salts of chitosan (HMDC) of chitosan derivates. The 及細胞相容性，據以提升含多酚結構之四級銨鹽化幾丁聚醣 antioxidant capacity of HMDC-GA was measured by DPPH 衍生物於紡織及生物醫學領域之應用。 (1,1-Diphenyl-2-picrylhydrazyl)- radical scavenging activity assay. The antibacterial activity was tested against Staphylococus aureus (S. aureus) by calculation of the 2.實驗 minimum inhibitory concentration (MIC). The results showed 2.1 HMDC-GA 之製備 HMDC-GA antibacterial activity against S. aureus. In addition 以自行合成之縮水甘油-甲基 - 二丙烯基四級銨鹽 to above results, the biocompatibility was evaluated by cell glycidyl-methyl-dially amonium salt (GMDAS)與幾丁聚醣反 cytotoxicity of mouse fibroblast with gallic acid and HMDC-GA. The results indicated that cytotoxicity of mouse 應來進行幾丁聚醣 2位置上氨基的修飾，合成 N-(2-羥基) 丙 fibroblast for HMDC-GA lower than gallic acid. 基-3-甲基二丙烯基四