冠心病患者血脂尿酸的临床意义
冠心病患者主要生化指标及C-反应蛋白的临床意义
洪凤芹 浙江省台州医院心血管内科 317000
[摘要]目的:探讨血尿酸(UA)、血脂(TC、TG、LDL-C、HDL-C)、C-反应蛋白(CRP)及胆红素(TBIL、BIL、DBIL)与冠心病的关系。方法:随机入选2006年1月至2009年6月我院收治的396例CHD患者作为观察组,同时选取396例健康体检者作为对照组,比较两组UA、TC、TG、LDL-C、HDL-C、CRP、TBIL、BIL及DBIL水平。结果:观察组UA、TC、TG、LDL-C及CRP水平明显高于对照组,差异具有统计学意义(P0.05),且与冠心病病变程度呈正相关;HDL-C、TBIL、及BIL水平明显低于对照组,差异具有统计学意义(P0.05),且与冠心病病变程度呈负相关。结论:C-反应蛋白、尿酸、血脂及胆红素等实验室指标与冠心病的发生、发展密切相关,应该重视冠心病相关危险因素,早期干预,做到早期预防及治疗。
[关键词]冠心病;血脂;血清尿酸,C-反应蛋白;胆红素;相关性
The clinical significance of chief laboratory indexs on patients on coronary artery disease
[Abstract] Objective:To explore the relation between the level of blood uric acid(UA),serum lipid(TC,TG,LDL-C,HDL-C),C-reactive protein(CRP), bilirubin((TBIL,BIL,DBIL)and CHD . Method:A total of 396 patients with a diagnosis of CHD from January 2006 to June 2009 in our hospital were included in the study group,and 396 healthy people were selected as the control group. The difference in level of UA,TC,TG,LDL-C,HDL-C,CRP,TBIL,BIL and DBIL were compared in two groups. Result:The level of UA,TC,TG,LDL-C,HDL-C,CRP,TBIL and BIL were significantly different between the study group and the control group. The level of UA,TC,TG,LDL-C and CRP positively related with the severity of CHD. The level of HDL-C,TBIL and BIL negatively related with the severity of CHD. Conclusion: The level of blood uric acid,serum lipid,C-reactive protein(CRP)and bilirubin is likely to play a certain role in the genesis and progress of CHD. We must pay attention to the relative risk factors and early interve
[Key words] Coronary artery disease;Serum lipid;Blood uric acid;C-reactive protein;Bilirubin
冠心病(coronary heart disease,CHD)是继肿瘤之后严重威胁人类健康的重大疾病,随着生活模式及饮食习惯的改变,发病率逐年升高,严重危害人类生存质量和生命健康。CHD是一种多因素疾病,危险因素错综复杂,文献报道C-反应蛋白、尿酸、血脂及胆红素是冠心病的危险因素[1-2]。笔者对近年我院收治的398例CHD患者的C-反应蛋白、尿酸、血脂及胆红素等实验室指标进行回顾性分析,现报道如下。
资料与方法
1.1 一般资料 随机入选2006年1月至2009年6月我科收治的经冠状动脉造影确诊为CHD的患者396例作为观察组,其中男246例,女150例,年龄50岁至73岁,平均年龄63.82±5.32岁,均未服用吡嗪酰胺、利尿剂及促血尿酸排泄药,并排除恶性肿瘤、痛风、扩张性心肌病、风湿性心脏病、心衰、血液系统
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