多烯磷酯酰胆碱治疗甲亢性肝损害临床分析.docVIP

多烯磷酯酰胆碱治疗甲亢性肝损害临床分析 　　[摘要] 目的 探讨多烯磷酯酰胆碱治疗甲亢性肝损害的疗效。 方法 150例甲亢性肝损害患者随机分成两组，对照组给予肌苷治疗，观察组给予多烯磷酯酰胆碱治疗。 结果 观察组总有效率94.67%高于对照组总有效率68.00%，差异有统计学意义（P0.01）。治疗后，观察组ALP、AST、ALT水平均低于对照组，ALB水平高于对照组，差异均有统计学意义（P0.01）。 结论 多烯磷酯酰胆碱治疗甲亢性肝损害能有效促进患者肝功能的恢复，提高疗效，建议临床推广应用。 　　[关键词] 甲亢性肝损害；多烯磷酯酰胆碱；肌苷 　　[中图分类号] R575.5 [文献标识码] B [文章编号] 1673-9701（2015）01-0032-02 　　Clinical analysis of polyene phosphatidylcholine in treatment of hyperthyroidism hepatic damage 　　SHAO Licheng TAN Lijun PAN Aihuan 　　Department of Endocrinology， the Fifth Peoples Hospital of Foshan City in Guangdong Province， Foshan 528211， China 　　[Abstract] Objective To explore the effect of polyene phosphatidylcholine in treatment of hyperthyroidism hepatic damage. Methods 150 cases of hyperthyroid liver damage were randomly divided into two groups. The control group was given inosine treatment， while the observation group was treated with polyene phosphatidylcholine. Results The total effective rate of the observation group was 94.67% ， which was higher than 68.00% of the control group， the difference was statistically significant（P0.01）. After treatment， the levels of ALP， AST， ALT in the observation group were lower than those in the control group， ALB level of the observation group was higher than that of the control group， the differences were statistically significant （P0.01）. Conclusion Polyene phosphatidyl choline in the treatment of hyperthyroidism hepatic damage can effectively promote the recovery of liver function in patients， improve the curative effect， and it is recommended for clinical. 　　[Key words] Hyperthyroidism liver injury； Polyene phosphatidyl choline； Inosine 　　甲状腺机能亢进是内分泌系统的常见病、多发病，可累及全身多个器官，以心血管及神经系统多见，亦可累及肝脏引起肝损害、肝肿大，甚至肝硬化[1]。研究显示[2]甲亢患者合并肝脏损害现象，患者死亡率较高，因此甲亢合并肝损害患者在治疗甲亢疾病的同时需要积极改善恢复患者的肝功能。本研究中笔者采用多烯磷酯酰胆碱治疗甲亢性肝损害，取得较好效果，现报道如下。 　　1 资料与方法 　　1.1一般资料 　　选择2010年1月～2013年12月在我院就诊的甲亢性肝损害患者150例为研究对象，年龄31～78岁，病程6个月～15年。患者符合甲亢诊断标准，并经实验室检查均合并肝损害，且排除因饮酒、药物等其他原因造成的肝损害。随机分为观察组和对照组两组。对照组75例（男39例/女36例），年龄（53