头孢哌酮舒巴坦联合雾化吸入治疗AECOPD疗效及对肺功能影响.docVIP

头孢哌酮舒巴坦联合雾化吸入治疗AECOPD疗效及对肺功能影响 　　[摘要] 目的 整群探讨头孢哌酮舒巴坦联合雾化吸入治疗急性加重期慢性阻塞性肺疾病（AECOPD）的疗效及对肺功能的影响。方法 收集2015年6月―2016年5月在该院呼吸科接受治疗的102例AECOPD患者， 根据随机数字表法将患者分为实验组和对照组，每组51例。对照组采用常规方法治疗。实验组采用常规方法治疗同时给予头孢哌酮舒巴坦联合痰热清注射液雾化吸入治疗。比较两组疗效及观察治疗前后动脉血气和肺功能变化情况。结果 实验组的痊愈率（70.6%）及总有效率（88.2%）明显高于对照组的9.8%、68.6%（P0.05），治疗后实验组PaO2、PaCO2、FEV1、FVC分别为（8.2±2.1）mmHg、（44.1±7.4）mmHg、（3.3±0.4）L、（2.7±0.4）L，较对照组相应指标[（6.7±1.4）mmHg、（54.1±9.5）mmHg、（2.6±0.5）L、（2.4±0.3）L]明显改善（P0.05）。 结论 采用头孢哌酮舒巴坦联合雾化吸入治疗AECOPD可有效缓解患者相关症状，显著明显改善肺功能，提高疗效，是一种安全而有效的治疗选择。 　　[关键词] 头孢哌酮舒巴坦；雾化吸入；慢性阻塞性肺疾病 　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2017）02（b）-0138-03 　　[Abstract] Objective To discuss the curative effect of cefoperazone sulbactam combined with nebulization in treatment of AECOPD and effect on the lung function. Methods Convenient selection 102 cases of patients with AECOPD admitted and treated in our hospital from June 2015 to May 2016 were collected and randomly divided into two groups with 51 cases in each， the control group adopted the routine method， while the experimental group adopted the cefoperazone sulbactam combined with nebulization on the basis of the routine method， and the curative effect， arterial blood gas and lung function changes were compared between the two groups. Results The cure rate and total effective rate in the experimental group were obviously higher than those in the control group（70.6%， 88.2% vs 9.8%，68.6%）（P0.05）， after treatment， the PaO2，PaCO2，FEV1，FVC in the experimental group after treatment were obviously improved compared with those in the control group[（8.2±2.1）mmHg （44.1±7.4）mmHg， （3.3±0.4）L， （2.7±0.4）L vs （6.7±1.4）mmHg， （54.1±9.5）mmHg， （2.6±0.5）L， （2.4±0.3）L]（P0.05）. Conclusion The cefoperazone sulbactam combined with nebulization in treatment of AECOPD can effectively relieve the related symptoms of patients， obviously improve the lung function and improve the curative effect， which is a safety and effective treatment choice. 　　[Key words] Cefoperazone sulbactam； Nebulizatio