头孢呋辛不同给药方式干预治疗呼吸机相关性肺炎临床观察.docVIP

头孢呋辛不同给药方式干预治疗呼吸机相关性肺炎临床观察 　　【摘要】 目的 ?^察头孢呋辛不同给药方式干预治疗呼吸机相关性肺炎（VAP）患者的临床疗效。方法 60例VAP患者， 通过信封法随机分为对照组和试验组， 每组30例。对照组应用阿米卡星联合头孢呋辛注射液静脉滴注治疗干预方式， 试验组应用阿米卡星静脉滴注联合头孢呋辛静脉滴注及口服治疗干预方式， 观察比较两组患者治疗前后血常规变化情况及临床疗效。结果 治疗前， 两组患者的白细胞计数（WBC）、C反应蛋白（CRP）水平比较差异无统计学意义（P0.05）。治疗后， 对照组WBC为（10.30±2.16）×109/L、CRP为（24.20±7.19）mg/L， 明显高于试验组的（7.30±2.11）×109/L、（17.10±5.26）mg/L， 差异具有统计学意义（P0.05）。对照组患者的总有效率为80.0%， 明显低于试验组的96.7%， 差异具有统计学意义（P0.05）。结论 阿米卡星静脉滴注联合头孢呋辛静脉滴注及口服治疗VAP患者临床疗效优于静脉单一给药方式， 起效快、疗效确切、安全可靠、副作用小， 可加速患者肺内炎症消退及呼吸机通气戒断， 临床疗效优异， 值得推广。 　　【关键词】 不同给药方式；口服治疗；头孢呋辛；呼吸机相关性肺炎 　　DOI：10.14163/j.cnki.11-5547/r.2018.14.054 　　Clinical observation on different administrations of cefuroxime in the treatment of ventilator-associated pneumonia QIAO Hong-chun. Department of Respiratory， Fushun Hospital of Traditional Chinese Medicine， Fushun 113006， China 　　【Abstract】 Objective To observe the clinical efficacy of different administrations of cefuroxime in the treatment of patients with ventilator-associated pneumonia （VAP）. Methods A total of 60 VAP patients were divided by envelope method into control group and experimental group， with 30 cases in each group. The control group received amikacin combined with intravenous drip of cefuroxime for treatment， and the experimental group received intravenous drip of amikacin and intravenous drip and oral administration of cefuroxime for treatment. Observation and comparison were made on routine blood test changes before and after treatment and clinical efficacy between the two groups. Results Before treatment， both groups had no statistically significant difference in white blood cell （WBC） and C-reactive protein （CRP） level （P0.05）. After treatment， the control group had WBC as （10.30±2.16）×109/L， CRP as （24.20±7.19 ） mg/L， which were all obviously higher than （7.30±2.11）×109/L and （17.10±5.26） mg/L in the experimental group. Their difference was statistically significant （P 　　【Key words】 Different administrations； Oral treatment； Cefuroxime； Ventilato