子宫内膜癌组织中SmacBcl―2Survivin 和 Bax表达临床意义.docVIP

子宫内膜癌组织中SmacBcl―2Survivin 和 Bax表达临床意义 　　[摘要] 目的 通过免疫组织化学SP法检测子宫内膜癌细胞中Smac、Bcl-2、Survivin 和 Bax的表达情况，寻找子宫内膜癌新的有效的检测分子，为子宫内膜癌的早期发现和诊断、监测复发和转移、判断疗效和预后提供指标。 方法 选取2011年2月～2013年9月来我院接受手术治疗的子宫内膜癌患者80例，同时选取52例正常子宫内膜组织和39例子宫内膜不典型增生组织。 结果 Smac、Bcl-2、Survivin和Bax在三种组织中阳性表达差异显著（P0.05）。Smac与Bcl-2、Survivin在子宫内膜癌组织中阳性表达均呈负相关（rBcl-2=-0.398、rSurvivin=-0.335，P0.05），而与Bax呈正相关（rBax=0.458，P0.05）；而Bcl-2与Survivin阳性表达呈正相关（rSurvivin=0.581，P0.05），而与Bax呈负相关（rBax=-0.477，P0.05）；Bax与Survivin阳性表达呈负相关（r=-0.511，P0.05）。 结论 对疑似子宫内膜癌患者进行Smac、Bcl-2、Survivin 和 Bax表达的检测以进行进一步确诊，提高临床确诊率，为今后的临床治疗方案提供新的治疗靶点和思路。 　　[关键词] 子宫内膜癌； 第二线粒体源性激活半胱天冬酶； B淋巴细胞瘤-2基因； 凋亡抑制基因； 促凋亡因子 　　[中图分类号] R737.33 [文献标识码] A [文章编号] 1673-9701（2016）23-0001-03 　　[Abstract] Objective To explore the expression of Smac， Bcl-2， Survivin in endometrial cancer cells by immunohistochemical SP method in patients with endometrial cancer， and to provide new indicators for early detection and diagnosis， monitoring of recurrence and metastasis， and determination of efficacy and prognosis of endometrial cancer. Methods 80 patients with endometrial cancer surgically treated in our hospital from February 2011 to September 2013 were selected， and another 52 cases of normal endometrial tissue， and 39 cases of atypical endometrial hyperplasia were also selected. Results There were significant differences in expression of Smac， Bcl-2， Survivin， and Bax in these three kinds of tissues（P0.05）. The positive expression of Smac had a negative relation with Bcl-2 and Survivin in endometrial cancer tissue（rBcl-2= -0.398， rSurvivin=-0.335， P0.05）， and had a positive relation with Bax （rBax=0.458， P0.05）. The positive expression of Bcl-2 had a positive relation with Survivin （rSurvivin=0.581， P0.05）， and had a negative relation with Bax（rBax=-0.477， P0.05）. The positive expression of Bax had a negative relation with Survivin（r=-0.511， P0.05）. Conclusion Detection of Smac， Bcl-2， Survivin， and Bax expression in patients suspected with endometrial cancer can furthe