不同剂量阿托伐他汀对对比剂肾病高危患者介入术后肾功能及炎症反应影响-内科学(心血管病)专业论文.docxVIP

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不同剂量阿托伐他汀对对比剂肾病高危患者介入术后肾功能及炎症反应影响-内科学(心血管病)专业论文.docx

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不同剂量阿托伐他汀对对比剂肾病高危患者介入术后肾功能及炎症反应影响-内科学(心血管病)专业论文

PAGE PAGE 7 higher than that in the 80 mg statin group (P0.05). Cys C decreased to baseline level at 48 hours after the procedure (P0.05). (3) The urinary α1-MG, TRF and mALB levels at admission were not significantly different among the three groups (P0.05). In the 80 mg statin group, these three items had no significant change after the procedure compared to baseline (P0.05). In the 40 mg statin group, urinary α1-MG significantly increased at 24 hours after PCI (P0.05), and recovered to baseline level at 48 hours after PCI (P0.05). In the 20 mg statin group, urinary α1-MG significantly increased after the procedure (P0.05), and was higher than that in the 80 mg statin group (P0.05). In the 40 mg and 20 mg statin groups, urinary TRF and mALB significantly increased after the procedure (P0.05). At 24 hours after PCI, urinary TRF and mALB were significantly higher in the 20 mg statin group than that in the 40 mg and 80 mg statin groups (P0.05), urinary mALB was greater in the 40 mg statin group than that in the 80 mg statin group (P0.05). At 48 hours after PCI, the levels of urinary TRF were not significantly different among the three groups (P0.05), urinary mALB was higher in the 20 mg statin group than that in the 40 mg and 80 mg statin groups (P0.05). (4) Incidences of CIN in the 80 mg statin group, 40 mg statin group and 20 mg statin group were 11.1%, 10.7% and 35.7% respectively. Cases of CIN in these three groups were 3, 3 and 10. The patients in the 20 mg statin group had a higher incidence of CIN than that in the 40 mg and 80 mg statin groups (P0.05). (5) The levels of hs-CRP, Fib, IL-6 and APN at admission were not significantly different among the three groups (P0.05). At 24 and 48 hours after the procedure, hs-CRP and IL-6 significantly increased (P0.05), and were higher in 20 mg statin group than that in the 40 mg and 80 mg statin groups (P0.05). At 48 hours after PCI, Fib significantly increased in the three groups (P0.05). At 24 hours after the proce