左氧氟沙星联合头孢曲松钠治疗社区获得性肺炎临床疗效及安全性评价.docVIP

左氧氟沙星联合头孢曲松钠治疗社区获得性肺炎临床疗效及安全性评价 　　[摘要] 目的 探讨左氧氟沙星联合头孢曲松钠治疗社区获得性肺炎的临床疗效及安全性评价。 方法 选取我院2013年6月～2016年6月收治的社区获得性肺炎患者60例，按随机数字表法分为对照组（n=30）和观察组（n=30）。对照组给予注射用头孢曲松钠治疗；观察组在对照组治疗的基础上给予左氧氟沙星注射液治疗；两组均治疗1周。比较两组患者临床症状及体征发热、咳痰、肺部??音及喘?Q音改善时间；比较两组患者致病菌清除率及住院时间；比较两组患者治疗有效率；并观察两组患者恶心呕吐、头痛失眠、皮疹等不良反应发生率情况。 结果 观察组发热、咳痰、肺部??音及喘鸣音改善时间均明显较对照组缩短（P0.05）。 结论 左氧氟沙星联合头孢曲松钠治疗社区获得性肺炎的临床疗效显著，可有效缓解患者临床症状，缩短住院时间，提高临床疗效，且不良反应少，安全有效，值得临床上推广。 　　[关键词] 左氧氟沙星；头孢曲松钠；获得性肺炎；安全性 　　[中图分类号] R563.1 [文献标识码] A [文章编号] 2095-0616（2017）11-59-03 　　Clinical curative effect and safety evaluation of levofloxacin combined with ceftriaxone sodium in treatment of community acquired pneumonia 　　ZHENG Xueqiong1 ZHAI Yanzhen2 ZHU Caihong1 　　1.Department of Pharmacy， the Fifth Affiliated Hospital of Southern Medical University， Guangdong， Guangzhou 510900， China； 2. Department of Respiratory Medicine， the Fifth Affiliated Hospital of Southern Medical University， Guangdong， Guangzhou 510900， China 　　[Abstract] Objective To explore the clinical curative effect and safety evaluation of levofloxacin combined with ceftriaxone sodium in treatment of community acquired pneumonia. Methods 60 patients with community acquired pneumonia who were admitted to our hospital from June 2013 to June 2016 were selected. They were divided into the control group and the observation group according to random number table， with 30 in each. The control group was treated with ceftriaxone sodium for injection. The observation group was treated with levofloxacin for injection at basis of the control group. They were all treated for 1 week. Clinical symptoms and signs such as fever， expectoration， pulmonary rales and wheezing of two groups were compared. Bacterial clearance rate， hospital stay and effective rate of patients in two groups were also compared. Rates of adverse actions such as nausea， vomiting， headache， insomnia， rash and so on of patients in two groups were observed. Results Improvement time for fever， expectoration， pulmonary rale