左西孟旦对慢性心力衰竭室性心律失常影响.docVIP

左西孟旦对慢性心力衰竭室性心律失常影响 　　[摘要] 目的 观察左西孟旦治疗慢性心力衰竭室性心律失常的效果。 方法 选择河南省南阳市第九人民医院2012年1月～2015年1月收治的慢性心力衰竭室性心律失常患者106例作为研究对象，依据随机数字表法分成两组，每组53例。观察组首先给予左西孟旦12 μg/kg负荷量，以0.05 μg/（kg?min）为初始剂量静脉泵入，维持剂量调整范围为0.05～0.20 μg/（kg?min），保证收缩压≥90 mmHg，持续泵入24 h，同时口服氯化钾缓释片1 g，3次/d；对照组首先给予米力农50 μg/kg负荷量，然后以0.375 μg/（kg?min）剂量持续24 h静脉泵入。比较两组治疗前后呼吸困难程度评分、每搏输出量（SV）、左室射血分数（LVEF）、左室舒张末容积（LVEDV）、脑钠肽前体（pro-BNP）、血压、心率、短阵室性心动过速次数及室性期前收缩次数，评价两组室性心律失常疗效、心功能疗效及不良反应情况。 结果 观察组患者治疗后呼吸困难程度评分低于治疗前及对照组，SV、LVEF高于治疗前及对照组，LVEDV小于治疗前，差异有统计学意义（P 0.05）。 结论 左西孟旦应用于慢性心力衰竭室性心律失常患者比米力农能更有效地减少室性心律失常的发生。 　　[关键词] 左西孟旦；心力衰竭；心功能；室性心律失常 　　[中图分类号] R541.6 [文献标识码] A [文章编号] 1673-7210（2016）03（c）-0169-04 　　[Abstract] Objective To observe effect of Leosimendan in the treatment of chronic heart failure complicated with ventricular arrhythmia. Methods 106 patients of chronic heart failure complicated with ventricular arrhythmia in the Ninth People′s Hospital of Nanyang City， He′nan Province from January 2012 to January 2015 were selected as research objects. All patients were divided into two groups according to random number table method， each group had 53 cases. Observation group was first given Levosimendan 12 μg/kg load， with 0.05 μg/（kg?min） for the initial dose intravenous pumping， maintenance dose adjustment range was 0.05-0.20 μg/（kg?min）， systolic blood pressure was not less than 90 mmHg， continued to pump into 24 h. At the same time， oral Potassium Chloride Sustained-release Tablets 1 g， 3 times/d. Control group was first given Milrinone Injection 50 μg/kg load， with 0.375 μg/（kg?min） for the initial dose intravenous pumping last 24 h. MMRC， SV， LVEF， LVEDV， pro-BNP， blood pressure， heart rate， the number of burst ventricular tachycardia and ventricular premature contraction before and after treatment between two groups were compared. Ventricular arrhythmia effect， cardiac function effect and adverse reaction between two groups were evaluated. Results After treatment， MMRC of observation group was lower than that befo