自体骨髓间充质干细胞治疗肝硬化的疗效及影响因素研究-effect of autologous bone marrow mesenchymal stem cells on liver cirrhosis and its influencing factors.docxVIP

IV IV 摘要 关键词：骨髓间充质干细胞；移植；肝硬化；疗效；影响因素；分析 Abst Abstract V V ABSTRACT Backgroud and Objective: Liver cirrhosis (LC) is a common disease in clinical, which often dead from one or more complications, such as upper gastrointestinal hemorrhage (UGH), Spontaneous bacterial peritonitis (SBP), hepatic encephalopathy, primary hepatic carcinoma (PHC) and hepatorenal syndrome (HRS). According to the studies of 2010 global burden of disease showed that there were more than several millions people died of liver cirrhosis. Liver disease has been one of the leading causes of morbidity and mortality in the world. Recent years, bone marrow mesenchymal stem cells (BM-MSCs) transplantation has been applied to the treatment of liver diseases, but its safty and efficacy were controversy. This study is to understand the efficacy, influence factors and safety. Methods: The studies include two aspects: Meta analysis: The system searched in the Cochrane Library, Med-Line (Pub-Med) and Em-base. Journals were also hand-searched in this field. The retrieval time was from created database to February, 2014. 78 studies which used BM-MSCs in the treatment of any chronic liver disease were included. The control trail used Review Manager 5.1 software for analysis, the data before and after treatment used Meta-Analyst 3.13 software for statistical analysis. The clinical control trails study: LC patients treated with BM-MSCs transplantation plus basic treatment in our hospital during 2007 to 2012 were collected. The control group was conformed to inclusion and exclusion criteria and reasonable basic treatment, matching with propensity scores matching by years, gender and diseases category of the treatment group. The t-test was using to compare biochemical, blood coagulatin function and liver fribrosis indexes between two groups. Single factor analysis and the logistics regression analysis were used to test the influence factors of efficacy and tumorigenesis after transfusion. Using Kaplan-Meier to anal