探讨血清中αl―微球蛋白同型半胱氨酸和胱抑素C在2型糖尿病肾病患者检测中意义.docVIP

探讨血清中αl―微球蛋白同型半胱氨酸和胱抑素C在2型糖尿病肾病患者检测中意义 　　[摘要] 目的 探?对2型糖尿病肾病患者实施相关临床指标进行检测的效果与临床意义。方法 方便收集50例2型糖尿病肾病患者的临床资料予以回顾性分析研究，资料收集时间为2015年1月―2016年12月。将这50例患者设为实验组，另从同期在该院接受体检的人群中随机选择50名设为健康对照组。于清晨空腹状态下采集两组研究对象的静脉血，检测同型半胱氨酸以及胱抑素C水平。另收集两组的中段晨尿送检，采用免疫散射比浊法检测α1-微球蛋白水平。结果 两组研究对象在平均年龄以及平均体质量等方面情况基本相同，各项临床指标经比较差异无统计学意义（P0.05）。对两组研究对象的α1-微球蛋白、同型半胱氨酸和胱抑素C水平进行检测，记录检测结果并进行组间统计学比较可得，实验组检测水平分别为（19.85±5.02）mg/L、（15.78±3.12）μmol/L、（1.51±0.45）mg/L，均显著高于对照组的（3.75±1.27）mg/L、（9.12±2.35）μmol/L、（0.62±0.21）mg/L（P0.05）。结论 对2型糖尿病肾病患者的血清中α1-微球蛋白、同型半胱氨酸和胱抑素C指标进行检测可较为直观的了解到患者的肾脏功能损伤情况，为临床诊治提供一定的参考依据。 　　[关键词] 2型糖尿病；并发症；糖尿病肾病；αl-微球蛋白；同型半胱氨酸；胱抑素C 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）05（a）-0001-03 　　[Abstract] Objective To investigate the effect and clinical significance of the implementation of relevant clinical indicators in patients with type 2 diabetic nephropathy. Methods Convenient selection 50 patients with type 2 diabetic nephropathy were collected and analyzed retrospectively. The data were collected from January 2015 to December 2016. The 50 patients were divided into the experimental group， and the other patients were randomly selected from the same period in our hospital to receive medical examination， and the other 50 cases were randomly divided into healthy control group. Venous blood was collected from two groups of subjects in the early morning fasting state， and the levels of homocysteine and cystatin C were detected. Another group of two groups were collected in the morning urine， using immune scattering turbidimetry to detect the level of alpha 1. Results The average age and average body weight of the two groups were basically the same， and there was no significant difference between the two groups（P0.05）. Detection of two groups of alpha 1- microglobulin， homocysteine and cystatin C levels， record test results and treatment groups were statistically compared to the experimental group， the detection level respectively （19.85±5.02）mg/L，（15.78±3.12）μmol/L，（1.51±0.45）mg/L，were