氯吡格雷联合阿托伐他汀治疗不稳定型心绞痛疗效观察及安全性评价.docVIP

氯吡格雷联合阿托伐他汀治疗不稳定型心绞痛疗效观察及安全性评价 　　[摘要] 目的 ?β冗粮窭琢?合阿托伐他汀治疗不稳定型心绞痛的疗效及安全性进行评价。 方法 将入选的60 例不稳定型心绞痛患者随机分为对照组与观察组，每组30例，分别予以常规治疗及在常规治疗的基础上应用氯吡格雷联合阿托伐他汀治疗；对两组患者治疗后的临床疗效进行比较分析，并进行安全性评价。 结果 观察组患者治疗后无效2例，占6.7%，总有效率93.3%。对照组患者治疗后无效9例，占30.0%，总有效率70.0%。观察组的临床疗效明显优于对照组（P0.05）。观察组治疗后心绞痛发作次数（0.52±0.11）次/min，对照组为（1.13±0.29）次/min，差异具有统计学意义（P0.05）。观察组患者治疗后心绞痛发作的持续时间（2.81±0.32）min/次，对照组为（4.48±1.12）min/次，两组比较差异具有统计学意义（P0.05）。观察组的不良反应发生率6.7%，显著低于对照组的不良反应发生率20.0%，组间比较差异具有统计学意义（P0.05）。 结论 对于不稳定型心绞痛患者，在常规治疗的基础上予氯吡格雷联合阿托伐他汀治疗，可以显著提高临床疗效，且安全性好，无明显不良反应，为不稳定型心绞痛的治疗方法的选择提供了参考依据。 　　[关键词] 氯吡格雷；阿托伐他汀；不稳定型心绞痛；安全性 　　[中图分类号] R541.4 [文献标识码] B [文章编号] 1673-9701（2017）27-0099-03 　　Observation on the efficacy of clopidogrel combined with atorvastatin in the treatment of unstable angina pectoris and its safety evaluation 　　Sadaite?Nuernijiati Taisaiergelin 　　Department of Geriatrics， Xinjiang Bozhou Peoples Hospital， Bozhou 833400， China 　　[Abstract] Objective To evaluate the efficacy and safety of clopidogrel combined with atorvastatin in the treatment of unstable angina pectoris. Methods 60 enrolled patients with unstable angina pectoris who were randomly divided into control group and observation group， with 30 patients in each group. The patients in the two groups were respectively given conventional treatment and were given clopidogrel combined with atorvastatin on the basis of the conventional treatment. The clinical efficacy of the two groups was compared after the treatment， and the safety evaluation was carried out. Results In the observation group， two cases were ineffective after treatment， accounting for 6.7%， with the total effective rate of 93.3%. In the control group， nine cases were ineffective after treatment， accounting for 30.0%， with the total effective rate of 70.0%. The clinical efficacy in the observation group was significantly better than that in the control group（P 　　[Key words] Clopidogrel； Atorvastatin； Unstable angina pectoris； Safety 　　不稳定型心绞痛（UAP）是介于急性心肌梗死和稳定型心绞痛之间的一种