甘露醇治疗脑出血应用效果与最佳剂量研究及分析.docVIP

甘露醇治疗脑出血应用效果与最佳剂量研究及分析 　　【摘要】 目的：研究分析甘露醇治疗脑出血的应用效果和最佳剂量。方法：采取随机对照试验法在2014年7月-2016年5月本院收治的脑出血患者中选取76例作为观察对象，均使用甘露醇进行治疗。基于患者意愿和入院先后顺序，以药物剂量的不同将76例脑出血患者分为A组和B组，A组38例患者以常规剂量（250 mL/次）使用甘露醇治疗，B组38例患者以小剂量（150 mL/次）使用甘露醇治疗，对比分析两组患者治疗效果和肾功能受损情况。结果：A组和B组的治疗总有效率分别为84.2%、86.8%，两组比较差异无统计学意义（P0.05）；B组的肾功能损害程度明显轻于A组，差异有统计学意义（P0.05）。结论：在脑出血的临床中以小剂量使用甘露醇治疗，安全可靠，毒副作用少，疗效显著，值得临床应用与推广。 　　【关键词】 甘露醇； 脑出血； 肾功能 　　Study on the Effect and Optimal Dose of Mannitol in the Treatment of Cerebral Hemorrhage/OU Xiao-sheng.//Medical Innovation of China，2017，14（03）：112-114 　　【Abstract】 Objective：To study the application effect and optimal dose of Mannitol in the treatment of cerebral hemorrhage.Method：A randomized controlled trial was carried out in 76 patients with cerebral hemorrhage who were treated in our hospital from July 2014 to May 2016，all patients were treated with mannitol.The willingness of patients and the order of admission to the different drug dose based on 76 cerebral hemorrhage patients were divided into A group and B group，A group of 38 patients with conventional dose（250 mL/time） Mannitol treatment，B group of 38 patients with small dose（150 mL/time） used Mannitol treatment，comparative analysis of two groups patients with impaired renal function.Result：The total effective rates of A group and B group were 84.2%，86.8%，there was no statistically significant difference（P0.05）；the degree of renal dysfunction，B group was significantly lighter than that in A group，the difference was statistically significant（P0.05）.Conclusion：In the clinical application of small doses of mannitol in the treatment of cerebral hemorrhage，safe and reliable，less toxic side effects，significant efficacy，worthy of clinical application and promotion. 　　【Key words】 Mannitol； Cerebral hemorrhage； Renal function 　　First-author’s address：Shantou Chaonan Minsheng Hospital，Shantou 515144，China 　　doi：10.3969/j.issn.1674-4985.2017.03.033 　　?X出血即非外伤性脑是指内血管破裂所致出血，在全部脑卒中所占比重在20%～30%，其中急性期病死率可达30%～40%[1-2]。脑出血患者多