甲地孕酮联合TCF化疗方案对晚期胃癌患者生活质量影响.docVIP

甲地孕酮联合TCF化疗方案对晚期胃癌患者生活质量影响 　　[摘要] 目的 观察甲地孕酮联合TCF（紫杉醇+顺铂+氟尿嘧啶）化疗方案对晚期胃癌患者生活质量的影响。 方法 将56例晚期胃癌患者随机分为实验组（29例）和对照组（27例）。实验组采用TCF方案化疗+口服甲地孕酮，对照组仅采用TCF方案化疗，均化疗2个周期。观察患者化疗前后的生活质量评分、食欲、体重变化情况及不良反应发生情况。 结果 两组化疗前KPS评分差异无统计学意义（P0.05）。实验组化疗后KPS评分较化疗前差异无统计学意义（P0.05）。对照组KPS较化疗前降低，差异有统计学意义（P0.05）；两组患者化疗后KPS比较，实验组明显高于对照组，差异有统计学意义（P0.05）；实验组的食欲增加、体重增加亦优于对照组，差异有统计学意义（P0.05），且不良反应少（P0.05）。 结论 甲地孕酮联合TCF化疗方案治疗胃癌晚期，可以明显改善患者的生活质量，降低化疗药物的毒副作用，增加对化疗的依从性。 　　[关键词] 甲地孕酮；晚期胃癌；生活质量 　　[中图分类号] R735.2 [文献标识码] A [文章编号] 1674-4721（2014）04（b）-0082-03 　　[Abstract] Objective To observed impact of Megestrol joint TCF （paclitaxel+cisplatin+fluorouracil） chemotherapy on life quality in patients with advanced gastric cancer. Methods Fifty-six patients with advanced gastric cancer were randomly divided into the treatment group in 29 patients and the control group in 27 cases.The patients in the treatment group were administrated with TCF+ megestrol，while the others in the control group were administrated with TCF.All the patients were treated for two courses.The diversification of Karpofsky performance status （KPS） scores，appetite，body weight and adverse reactions between the 2 groups were observed and compared. Results There was no statistical difference in the KPS scores between the two groups before treatment （P0.05）.There was no statistical difference in the KPS scores of the treatment group between before and after treatment （P0.05），but the KPS scores of the control group after treatment were lower than before，there was statistical difference （P0.05）.There was statistical difference in the KPS scores between the two groups after treatment，the control group were lower than the treatment group （P0.05）.The treatment group was superior to the control group in the aspect of increased appetite and weight gain （P0.05）.And the treatment group had fewer adverse reactions than the control group （P0.05）. Conclusion Megestrol joint TCF chemotherapy in the treatment of patients with advanced gastric cancer can s