经电子支气管镜下冷冻联合化疗治疗晚期中央型肺癌疗效观察.docVIP

经电子支气管镜下冷冻联合化疗治疗晚期中央型肺癌疗效观察 　　【摘要】 目的：应用电子支气管镜下冷冻治疗联合化疗对晚期中央型肺癌的疗效分析。方法：选取24例晚期中央型肺癌为治疗组，随机设置24例晚期中央型肺癌（拒绝行电子支气管镜介入冷冻治疗）为对照组，给予标准化疗方案。治疗组采用OLYMPS BF-260电子支气管镜冷冻介入治疗联合（多西他赛+卡铂）方案全身静脉化疗。对照组采用单纯（多西他赛+卡铂）方案全身静脉化疗。结果：治疗组24例患者中，完全缓解（CR）8例，部分缓解（PR）12例，稳定（SD）2例，疾病进展（PD）2例，有效率（CR+PR）为83.3%；对照组24例患者中，CR2例，PR11例，SD7例，PD4例，有效率为54.2%。两组有效率比较差异有统计学意义（P0.01）。治疗组和对照组平均无疾病进展时间（progression-free survival PFS）分别为183 d和92 d，差异有统计学意义（P0.05）。结论：经电子支气管镜冷冻联合化疗治疗晚期中央型肺癌有较好的疗效，可提高晚期非小细胞肺癌的生存率。 　　【关键词】 肺肿瘤； 冷冻； 化疗； 电子支气管镜 　　中图分类号 R734.2 文献标识码 B 文章编号 1674-6805（2015）30-0021-03 　　【Abstract】 Objective：To observe the treatment efficiency of the patients with advanced stage central type lung cancer by using electronic bronchoscope cryotherapy， combined with chemotherapy.Method：24 patients with advanced stage central type lung cancer were selected the treatment group， 24 patients with advanced stage central type lung cancer were randomly selected of the control group（refused to row electronic bronchoscope in cryotherapy），who were gived the standard chemotherapy regimens.The treatment group was treated with OLYMPS BF-260 electronic bronchoscopic cryotherapy and combined intravenous chemotherapy with the Docetaxel + Carboplatin， while the control group with intravenous chemotherapy with the Docetaxel + Carboplatin.Result：In the treatment group ，complete remission（CR） was 8 cases， partial remission（PR） was 12 cases， stable disease（SD） was 2 cases，progresive disease（PD） was 2 cases.In the control group ，CR was 2 cases，PR was 11 cases，SD was 8 cases，PD was 4 cases.The effective rate（CR+PR） of treatment group was significantly higher than that of the control group（83.3% vs 54.2%，P0.01）.The progression-free survival of the treatment group was significantly higher than that of the control group （183 days vs 92 days，P0.05）.Conclusion：The electronic bronchoscopic cryotherapy combined with chemotherapy not only has high curative effect but improve the survival rate of patients with advanced non-small cell