腹腔镜联合GnRH―a和LNG―IUS治疗子宫腺肌病临床研究.docVIP

腹腔镜联合GnRH―a和LNG―IUS治疗子宫腺肌病临床研究 　　【摘要】 目的：探讨研究腹腔镜联合促性腺释放激素激动剂（GnRH-a）和放置左炔诺孕酮宫内缓释系统（LNG-IUS）治疗明显增大的子宫腺疾病的临床效果。方法：将本院收治的子宫腺疾病患者60例随机分为两组各30例，所有患者在麻醉后，行腹腔镜子宫腺疾病灶挖除术，观察组患者术后应用GnRH-a和LNG-IUS进行治疗，对照组患者应用三烯酮治疗，观察两组治疗效果。结果：术后应用药物6、12、18、24个月后进行疼痛评分、月经量、子宫体积、血红蛋白含量比较，观察组均优于对照组，比较差异均有统计学意义（P0.05）。结论：对子宫腺疾病患者应用腹腔镜联合GnRH-a和LNG-IUS进行治疗优于腹腔镜联合孕三烯酮，值得临床推广探讨应用。 　　【关键词】 腹腔镜； GnRH-a； LNG-IUS； 子宫腺疾病 　　Study of Laparoscopy Combined with GnRH-a and LNG-IUS in Treatment of Uterine Gland Diseases/CHEN Qiu-lian.//Medical Innovation of China，2016，13（17）：055-058 　　【Abstract】 Objective：To investigate the clinical effects of laparoscopy combined with gonadotropin-releasing hormone agonist （GnRH-a） and place levonorgestrel releasing intrauterine system （LNG-IUS） in treatment of significantly increased uterine gland diseases.Method：A total of 60 patients with adenomyosis disease admitted to hospital were randomly divided into two groups，each group had 30 cases，all patients after anesthesia，laparoscopic uterine gland disease foci excavation operation，the observation group were postoperative GnRH-a and LNG-IUS treatment，the control group patients given gestrinone therapy，therapeutic effects were observed.Result：Postoperative drugs 6，12，18，24 months after pain scores，menstrual flow，uterine volume，hemoglobin content were compared，the observation group were better than the control group，and the differences were statistically significant（P0.05）.Conclusion：Patients with adenomyosis disease combined with GnRH-a laparoscopy and LNG-IUS treatment is superior to laparoscopic joint gestrinone， worthy of clinical application to explore. 　　【Key words】 Laparoscopy； GnRH-a； LNG-IUS； Adenomyosis disease 　　First-author’s address：The People’s Hospital of Xinyu，Xinyu 338025，China 　　doi：10.3969/j.issn.1674-4985.2016.17.015 　　子宫腺肌病是指子宫内膜向肌层良性浸润并在其中弥漫性生长，育龄期妇女常见妇女，临床上较常见而且治疗较困难。近年来，发病率逐渐增高，有年轻化趋势[1-3]。其特征是子宫肌层可检出异位的内膜和腺体，常伴有周围基层细胞的肥大和增生，所有子宫腺疾病也称为子宫内膜异位症，盆腔内子宫内膜异位症则称为子宫外子宫内膜异位症，两者的相同之处是由卵巢激素的进行调节，但是许多学者认为两者不是