脐血C反应蛋白检测对新生儿宫内细菌感染诊断价值.docVIP

脐血C反应蛋白检测对新生儿宫内细菌感染诊断价值 　　[摘要]目的 探讨C反应蛋白（CRP）对新生儿宫内细菌感染的诊断价值。 方法 选取2014年1～12月在我院产科出生，有宫内细菌感染高危因素的新生儿，根据感染结局分为感染组及无感染组，检测两组新生儿脐血、外周血CRP，比较两组新生儿脐血CRP的阳性率及CRP水平的差异性，比较感染组脐血CRP与新生儿外周血CRP水平的差异性。 结果 共有107例新生儿纳入研究，其中感染组30例，无感染组77例。感染组脐血CRP水平、阳性率均明显高于非感染组，感染组新生儿外周血CRP水平高于脐血CRP水平，差异均有统计学意义（P0.05）。 结论 脐血CRP可作为宫内细菌感染早期诊断的参考指标，提高诊断的敏感度，指导临床抗生素使用。 　　[关键词] C-反应蛋白；宫内感染；新生儿 　　[中图分类号] R722 [文献标识码] B [文章编号] 2095-0616（2015）16-72-03 　　Cord blood C-reactive protein as aids in the diagnosis of neonatal intrauterine bacterial infection 　　LI Li1 WANG Zhuliang2 WANG Guocheng2 SHEN Yingjie1 ZHAO Hui1 ZHANG Qian1 　　ZHAO Tianjiao1 YU Jinqian1 YI Huizhen1 　　1.Department of Neonatology， Maternal and Child Hospital of Shunyi District， Beijing 101300， China； 2.Clinical Laboratory， Maternal and Child Hospital of Shunyi District， Beijing 101300， China 　　[Abstract] Objective To evaluate the value of cord blood C reactive protein（CRP）in the diagnosis of intrauterine bacterial infections in newborn infants.Methods We conducted a prospective cohort study in newborns with risk factors for neonatal intrauterine bacterial infection in Maternal and Child Hospital of Shun yi District during 2014.Total of 107 newborn infants were divided into two groups：infection group and non-infection group.Cord blood CRP and neonatal blood CRP were measured，and analyzed for sensitivity，positivity and level.Results Cord blood CRP level and positivity are high- er in infection group than non-infection group. Neonatal blood CRP level is higher than cord blood in infection group. The difference was statistically significant（P0.05）. Conclusion This work investigated the role of the Cord blood C-reactive protein（CRP） in the diagnosis of neonatal intrauterine bacterial infection and therapy assessment in newborns is admitted. 　　[Key words] C-reactive protein； Intrauterine infection； Newborn 　　新生儿早发型感染于生后7d内发病，通常胎儿出生72h内即可发病，感染与围产期因素有关，多由母亲宫内细菌感染所致，可引起胎儿脑白质损伤，增加新生儿脑白质软化的发生率，是新生儿疾病和死亡的重要原因。然而早发型新生儿感染的诊断一直都是难点，很多感染的新生儿在出生