血清肿瘤标志物CEACA125和NSE在肺癌患者中水平变化及诊断意义.docVIP

血清肿瘤标志物CEACA125和NSE在肺癌患者中水平变化及诊断意义 　　[摘要]目的 探讨血清肿瘤标志物在肺癌患者中的水平变化及诊断意义。方法 采用Roche Elecsys 2010电化学发光全自动免疫分析仪检测肺癌组、肺良性病变组和健康体检组的血清标本中癌胚抗原（CEA）、肿瘤相关抗原（CA125）和神经原特异度烯醇化酶（NSE）的表达，并将这三组血清标本中CEA、CA125和NSE表达的检测结果进行分析。结果 肺癌组血清中的CEA、CA125和NSE的水平均明显高于其他两组，差异有统计学意义（P0.05）；CEA和NSE表达水平分别在肺腺癌和小细胞癌中高于其他两组，差异有统计学意义（P0.05）；CEA的灵敏度和特异度分别为46.56%和96.31%，高于其他两项指标。结论 CEA、CA125和NSE的表达与肺癌的发生和发展密切相关，且CEA和NSE分别在肺腺癌和小细胞癌中表达较高，CEA灵敏度和特异度较高，为进一步研究肺癌提供参考价值。 　　[关键词]血清肿瘤标志物；癌胚抗原；肿瘤相关抗原；神经原特异度烯醇化酶；肺癌；水平变化；诊断意义 　　[中图分类号] R734.2 [文献标识码] A [文章编号] 1674-4721（2016）09（b）-0137-03 　　[Abstract]Objective To investigate the level changes and its diagnostic significance of serum tumor markers in patients with lung cancer.Methods The expression of NSE，CA125 and CEA in the serum samples of lung cancer group，lung cancer group and healthy control group were detected by Roche Elecsys 2010 electrochemical luminescence immunoassay，the detection results of CEA，CA125 and NSE expression in three groups of serum samples were analyzed.Results The levels of serum CEA，CA125 and NSE in lung cancer group were significantly higher than the other two groups，and the difference was statistically significant （P 0.05）.The expression levels of CEA and NSE in lung adenocarcinoma and small cell carcinoma were higher than the other two groups，the differences were statistically significant （P 0.05）.The sensitivity and specificity of CEA was 46.56% and 96.31%，higher than the other two indicators.Conclusion The expression of CEA，CA125 and NSE is closely related to the occurrence and development of lung cancer.The expression of CEA and NSE in lung adenocarcinoma and small cell carcinoma are higher，and the sensitivity and specificity of CEA are higher.It can provide a reference value for the further study of lung cancer. 　　[Key words]Serum tumor markers；CEA；CA125；NSE；Lung cancer；Level change；Diagnostic significance 　　肺癌是严重威胁全球人类健康的恶性肿瘤之一，近年来随着人们生活环境和习惯的改变，死亡率呈逐年上升的趋势。目前，手术切除是肺癌主要的治疗方式，放疗和化疗是重要的辅助手段[1]。但由于目前还没有彻底能够治愈肺癌的方法，早发现以及早治疗仍是目前最