血清胱抑素C对妊娠早期肾损害诊断价值.docVIP

血清胱抑素C对妊娠早期肾损害诊断价值 　　[摘要] 目的 探讨采用血清胱抑素C联合尿微量清蛋白检测妊娠高血压早期肾损害的效果，为妊娠高血压合并肾损害治疗提供科学依据。 方法 随机选取68例2013年1月―2016年1月在该院就诊的妊娠高血压患者作为研究对象，同时随机选取68名同一时期在该院就诊的正常孕妇作为对照组，比较分析妊娠高血压患者和正常孕妇血清胱抑素C和尿微量清蛋白，独立检测及联合检测妊娠高血压疾病患者早期肾损害的敏感性和特异性。 结果 在研究组与对照组孕妇血清中胱抑素C含量对比（2.21±0.79） VS （0.69±0.12，尿中微量清蛋白含量对比（40.54±18.96） VS （20.17±15.41），差异有统计学意义（P0.05）；血清中胱抑素C和尿中微量清蛋白含量独立及联合检测比较，显示联合检测的特异性和敏感性分别为（97.1%、95.8%）均明显高于单独检测，差异具有统计学意义（P0.05）。结论 妊娠高血压患者采用血清胱抑素C联合尿微量清蛋白评估妊娠高血压早期肾损害效果显著，有利于在疾病的早期发现患者的肾损害，从而及早进行对症治疗，值得进一步推广和应用。 　　[关键词] 胱抑素C；微量清蛋白；妊娠；肾损害；诊断价值 　　[中图分类号] R714.258 [文献标识码] A [文章编号] 1674-0742（2016）07（b）-0030-03 　　Serum Cystatin C（CysC） and Urinary Albumin （mALB） in Diagnosis of Early Renal Damage in Pregnancy 　　LIANG Xing-lan，QIU Mei-rong，CHEN Yong-ping 　　Department of Nephrology， Second Hospital of longyan，Fujian Province， Longyan， Fujian Province ，364000 China 　　[Abstrct] Objective To investigate the clinical actual effect analysis combined with urine albumin in patients with pregnancy induced hypertension disease by detection of serum cystatin C in early renal damage， to provide a scientific basis for further effective treatment for the disease. Methods 68 cases were randomly selected in January 2013 -2016 year in January in our hospital for treatment of pregnancy induced hypertension patients as the research object， and randomly selected 68 cases of normal pregnant women during the same period of acceptance of delivery in our hospital as control group， comparative analysis of hypertension in normal pregnant women and patients with pregnancy blood albumin and urine cystatin C clear， single detection and two simultaneous detection of early renal damage in patients with hypertensive disorders in pregnancy sensitivity and specificity. Results In serum albumin content in cystatin C content and urine， study group of pregnant women were higher than the control group of pregnant women， the difference was statistically significant （P 　　[Key words] Cystatin C； Albumin； Pregnancy； Renal da