血清胱抑素C对急性心肌梗近期预后影响.docVIP

血清胱抑素C对急性心肌梗近期预后影响 　　【摘要】目的:评价血清半胱氨酸蛋白酶抑制物C（Cystatin C,CysC）对急性心肌梗存活患者近期预后的预测价值。方法:连续入选2010年6月至2011年2月我院收治的急性心肌梗死患者194例，24小时内测定血清CysC水平，根据血清CysC水平，分为正常血清CysC组和高血清CysC 组，观察两组患者Killip分级水平，2周内左室射血分数（LVEF），3个月内心血管事件（再次心肌梗死，心力衰竭，猝死），探讨血清CysC对急性心肌梗死存活患者近期预后的影响。结果:与正常血清CysC组相比，高血清CysC组年龄偏大〖（68.5±10.4）岁 vs（60.8±12.1）岁〗,多合并高血压病（64% vs 43%）、心肌梗死病史（20.9% vs 9.8%），Killip分级高〖（1.7±0.8）vs（1.3±0.6）〗,左室射血分数（LVEF）偏低〖（52.0±11.7）vs（58.8±11.0）〗，3个月内心血管事件高（15.1% vs 3.7%），差异均有统计学意义（P0.05）；二项logistic回归分析显示：血清CysC是急性心肌梗死存活患者3个月内发生心血管事件的独立危险因素（OR5.393, P0.022）。结论:血清CysC是急性心肌梗死存活患者近期预后的预测因子。 　　【关键词】急性心肌梗死；血清CysC；预后 　　【中图分类号】R542.22 【文献标识码】A 【文章编号】1008-6455（2011）12-0526-02 　　The Predictive Value of Cystatin C for Prognosis of Survival patients with acute myocardial infarction 　　Liu Shuhong Kong Lingjun Zong Wencang 　　【Abstract】Objective:To evaluate the predictive value of Cys C for short term Prognosis in Survival patients with myocardial infaction. Methods:194 Survival patients with acute myocardial infarction were included in our hospital from June 2010 to February 2011, which were divided into the normal Cys C group and the high Cys C group according to the level of Cys C. the level Killip classification and the left ventricular ejection fraction （LVEF） were observed in the two groups during hospitalization, the cardiac events were observed in 3-month follow-up. the relationship between Cys C and Prognosis of Survival patients with acute myocardial infarction were evaluated. Results:In the high CysC group, the mean age〖（68.5±10.4） years old vs （60.8±12.1） years old〗, the history of hypertension（64% vs 43%）, the history of myocardial infarction（20.9% vs 9.8%）,and the level of Killip classification〖（1.7±0.8） vs （1.3±0.6）〗 were higher than those in the normal CysC group, P0.05 respectively. the left ventricular ejection fraction （LVEF） 〖（52.0±11.7）% vs（58.8±11.0）%〗were lower than those in the normal CysC group, P 0.05. the cardiac events in 3-month follow-up （15.1% vs 3.7%）were higher t