血清胱抑素C联合尿RBP检验在糖尿病患者早期肾损伤中价值.docVIP

血清胱抑素C联合尿RBP检验在糖尿病患者早期肾损伤中价值 　　[摘要]目的 探讨糖尿病患者早期肾损伤血清胱抑素C（Cys C）联合尿视黄醇结合蛋白（RBP）检验的临床价值。方法 选取我院2015年6月～2016年6月的60例糖尿病早期肾损害患者作为观察组，联合检测所有患者的血清Cys C和尿RBP，与此同时选取同期于我院进行健康体检的60名健康人员作为对照组，测量其血清Cys C和尿RBP并进行对比，分析血清Cys C联合尿RBP检验对糖尿病患者早期肾损伤的临床诊断价值。结果 ?^察组的血清Cys C和尿RBP水平显著高于对照组，差异有统计学意义（P0.05）。血清Cys C联合尿RBP检测诊断糖尿病早期肾损伤的阳性检测率显著高于单独血清Cys C检测、尿RBP检测，差异有统计学意义（P0.05）。结论 血清Cys C联合尿RBP检验能够为糖尿病患者早期肾损伤的诊断提供可靠的检验依据，值得临床推广应用。 　　[关键词]糖尿病；早期肾损伤；血清Cys C；尿RBP 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721（2017）06（c）-0109-03 　　[Abstract]Objective To explore the clinical value of the joint detection of serum cystatin C （Cys C） and urinary retinol binding protcin （RBP） in the diagnosis of early renal damage for diabetic patients.Methods 60 diabetic patients with early renal damage treated in our hospital from June 2015 and June 2016 were selected as the observation group，and they all underwent joint detection of serum Cys C and urinary RBP.Simultaneously，60 cases of the healthy people undergoing medical examination in our hospital were selected as the control group，and they all underwent joint detection of serum Cys C and urinary RBP.A comarison was made in serum Cys C and urinary RBP between the two groups to analyze the clinical value of in the diagnosis of early renal damage for diabetic patients.Results The levels of serum Cys C and urinary RBP test results of the observation group were significantly higher than those of the control group，and the difference was statistically significant （P0.05）.The positive rate of joint detection of serum Cys C and urinary RBP in the diagnosis of early renal injury in diabetes was significantly higher than that in single serum CysC test and urine RBP test，with significant difference （P0.05）.Conclusion The joint detection of serum Cys C and urinary RBP can provide reliable basis for the diagnosis of early renal damage for diabetic patients，and it is worthy of clinical promotion and application. 　　[Key words]Diabetes；Early renal injury；Serum Cys C；Urinary