血清胱抑素―C测定在糖尿病患者早期肾损伤中意义.docVIP

血清胱抑素―C测定在糖尿病患者早期肾损伤中意义 　　[摘要] 目的 探讨血清胱抑素-C（cystatin，Cys-C）在诊断2型糖尿病患者早期肾损伤中的意义。 方法 选取本院2015年1月～2017年3月间收治的2型糖尿病患者90例，检测患者的空腹血清Cys-C、血肌酐（SCr）及尿白蛋白/肌酐比值（albumin creatinine rate，ACR）水平。根据ACR水平分为早期糖尿病肾病组及单纯糖尿病组，比较两组患者的Cys-C及SCr水平，并进行统计学分析。 结果 两组患者血清肌酐水平无明显差异，早期糖尿病肾病组其血清Cys-C水平显著高于单纯糖尿病组，差异具有统计学意义（P0.05）。Pearson相关分析显示血清Cys-C表达水平与ACR水平呈正相关（r=0.678，P0.05）。 结论 血清Cys-C测定可有效判断糖尿病患者早期肾脏损伤，可用于早期肾损伤的诊断。 　　[关键词] 血清胱抑素-C（Cys-C）；2型糖尿病；肾损伤；尿白蛋白/肌酐比值（ACR） 　　[中图分类号] R587.2；R692.9 [文献标识码] B [文章编号] 1673-9701（2017）34-0111-03 　　Significance of serum cystatin-C determination in diabetic patients with early renal injury 　　WANG Youxiang1 WU Qingxiu2 LIANG Xiaoliang1 ZHANG Yiqin1 　　1.Department of Laboratory， Xiamen Second Hospital， Xiamen 361021， China； 2.Department of Endocrinology， Xiamen Second Hospital， Xiamen 361021， China 　　[Abstract] Objective To investigate the significance of serum cystatin-C（Cys-C） in the diagnosis of early renal injury in type 2 diabetic patients. Methods 90 patients with type 2 diabetes mellitus admitted from January 2015 to March 2017 in our hospital were enrolled in this study. The fasting serum Cys-C， serum creatinine（SCr） and urinary albumin/creatinine（ACR） levels in patients were measured. According to the levels of ACR， the patients were divided into early diabetic nephropathy group and simple diabetic group. The levels of Cys-C and SCr in the two groups were compared and statistically analyzed. Results There was no significant difference in serum creatinine between the two groups. The serum Cys-C level in diabetic nephropathy group was significantly higher than that in simple diabetic group， and the difference was significant（P0.05）. Pearson correlation analysis showed that there was a positive correlation between serum Cys-C level and ACR level（r=0.678， P0.05）. Conclusion Serum Cys-C detection can effectively determine the early diabetic kidney injury in diabetic patients and can be used for the diagnosis of early renal injury. 　　[Key words] Seru