血清胱抑素C血C反应蛋白尿微量白蛋白联合检测早期诊断糖尿病肾病意义.docVIP

血清胱抑素C血C反应蛋白尿微量白蛋白联合检测早期诊断糖尿病肾病意义 　　[摘要] 目的 探讨血清胱抑素C、血C反应蛋白、尿微量白蛋白联合检测早期诊断糖尿病肾病的价值。 方法 收集2014年6月～2015年5月期间我院收治的早期糖尿病肾病患者共72例作为观察组，选取与观察组同期来我院进行健康体检的健康研究对象60例作为对照组，检测两组患者Cys-C、CRP、mALB水平，比较两组研究对象、不同性别早期糖尿病肾病患者Cys-C、CRP、mALB水平的差别及三项指标单独及联合检测的阳性率。 结果 观察组Cys-C、CRP、mALB水平与对照组比较明显较高，两组比较差异有统计学意义（P0.05）。 结论 糖尿病肾病患者Cys-C、CRP、mALB明显较高，不同性别的糖尿病肾病患者之间差别不大，三项指标联合检测阳性率明显提高，可作为预测早期糖尿病肾病的检测手段在临床推广使用。 　　[关键词] 糖尿病肾病；胱抑素C；C反应蛋白；微量白蛋白 　　[中图分类号] R587.2 [文献标识码] B [文章编号] 2095-0616（2015）19-166-03 　　[Abstract] Objective To explore significance of combined detection of serum cystatin C，serum C-reactive protein and microalbuminuria in early diagnosis of diabetic nephropathy. Methods 72 patients with early diabetic nephropathy who were admitted to our hospital from June 2014 to May 2015 were selected as the observation group.60 healthy people who received physical examination in our hospital in the same period were selected as the control group.Cys-C，CRP and mALB levels of two groups were detected.Differences of Cys-C，CRP and mALB levels of two groups and of different genders，positive rate of single detection and combined detection of three indexes were compared. Results Cys-C，CRP and mALB levels of the observation group were significantly higher than those of the control group and the difference was statistically significant（P0.05）. Conclusion Cys-C， CRP and mALB levels of patients with diabetic nephropathy are significantly higher and Cys-C，CRP and mALB levels of different genderss has no obvious differences.Combined detection three indexes of positive rate is significantly increased which is worthy of promotion and application in clinic as a detective method to predicate early diabetic nephropathy. 　　[Key words] Diabetic nephropathy；Cystatin C；C-reactive protein；Albumin 　　糖尿病是临床常见的一种慢性疾病，糖尿病肾病是其严重并发症之一，可导致肾小球和肾小管病变，引起肾功能不全，最终导致肾衰竭，尿毒症，是糖尿病患者致残、致死的主要原因[1-2]。肾脏本身的储备及代偿能力非常强大，早期糖尿病肾病无明显症状，由于该病病情隐匿，发展速度较慢，容易造成漏诊，严重影响患者的身体健康及生命安全，因此，糖尿病肾病的早期诊断具有重要的临床意义[3]。本研究收集72例早期糖尿病肾病患者，对其血清胱抑素（Cys-C）