超敏C―反应蛋白心肌酶测定与新生儿窒息程度关系分析.docVIP

超敏C―反应蛋白心肌酶测定与新生儿窒息程度关系分析 　　[摘要] 目的 探讨超敏C-反应蛋白（hs-CRP）、心肌酶测定与新生儿窒息程度的关系。 方法 选取2012年1月～2014年12月本院收治的123例窒息新生儿，根据出生后1 min内的新生儿Apgar评分，其中42例为重度窒息组，81例为轻度窒息组；选取本院同期顺产分娩的健康无窒息新生儿30例为对照组。3组新生儿在出生24 h内抽静脉血，测定血清中hs-CRP和心肌酶（AST、LDH、CK、CK-MB、α-HBDH），并作对比分析。 结果 重度窒息组的hs-CRP和心肌酶指标均高于轻度窒息组，差异有统计学意义（P0.05）；轻度窒息组的hs-CRP和心肌酶指标均高于对照组，差异有统计学意义（P0.05）。 结论 hs-CRP和心肌酶在窒息新生儿中均显著升高，且升高程度与窒息程度成正相关，可作为心肌损害及严重程度的评估指标。hs-CRP与心肌酶的测定对新生儿窒息所致心肌损害的早期诊断和预后评估有重要的临床价值。 　　[关键词] 超敏C-反应蛋白；心肌酶；新生儿窒息 　　[中图分类号] R722.12 [文献标识码] A [文章编号] 1674-4721（2015）07（c）-0103-03 　　The relevance between the degree of neonatal asphyxia and the determination of high sensitivity C-reactive protein and myocardial enzyme 　　XU Jian-min ZHOU Li-yin ZHAN Guo-hao 　　Clinical Laboratory，Maternal and Child Health Hospital of Yunfu City in Guangdong Province，Yunfu 527300，China 　　[Abstract] Objective To investigate the relevance between the degree of neonatal asphyxia and the determination of high sensitivity C-reactive protein（hs-CRP） and myocardial enzyme. Methods 123 cases of neonatal suffocation admitted into our hospital from January 2012 to December 2014 were selected.According to born within 1 min after the neonatal Apgar score，42 cases as severe asphyxia group and 81 cases as mild asphyxia group.30 cases of healthy and without asphyxia newborn baby at the same period in our hospital were selected as control group.Three groups were phlebotomized within 24h after birth to determine serum hs-CRP and myocardial enzyme（AST，LDH，CK，CK-MB，α-HBDH） for comparative analysis. Results The hs-CRP and myocardial enzyme in the severe asphyxia group were higher than those in the mild asphyxia group，the difference was statistically significant（P0.05）.The hs-CRP and myocardial enzyme in the mild asphyxia group were higher than those in the control group，the difference was statistically significant（P0.05）. Conclusion Both hs-CRP and myocardial enzyme were increased in asphyxial newborns.The degrees of elevation are positively correlated w