超敏C反应蛋白D―二聚体和纤维蛋白原在高血压内皮损伤中临床价值.docVIP

超敏C反应蛋白D―二聚体和纤维蛋白原在高血压内皮损伤中临床价值 　　【摘要】 目的 探?超敏C反应蛋白（hs-CRP）水平 、D-二聚体（D-Dimer）和纤维蛋白原（FIB）在高血压内皮损伤中的临床应用价值。方法 86例高血压患者， 按有无血管并发症分为重症组（41例）和轻症组（45例）， 另选取40例健康体检者进行对照作为无症组。分别检测三组人员的hs-CRP 、D-Dimer和FIB水平， 并进行比较分析。结果 高血压患者的 hs-CRP、D-Dimer和FIB水平与阳性率均明显高于无症组， 差异均具有统计学意义（P0.05）；重症组患者 hs-CRP为（9.56±3.15）mg/L、D-Dimer为（1.08±0.93）mg/L、FIB为（5.90±2.90）g/L， 均明显高于轻症组的（5.21±2.30）mg/L、（0.72±0.53）mg/L、 　　（4.80±1.90）g/L， 差异均具有统计学意义（P0.05）。且重症组上述指标阳性率分别为78.0%、70.7%、73.2%， 高于对照组的57.8%、51.1%、53.3%， 差异均具有统计学意义（P0.05）； 经过1周合理治疗， 重症组 hs-CRP、D-Dimer和FIB水平三项指标均明显下降， 差异具有统计学意义（P0.05）。结论 hs-CRP 、D-Dimer和FIB检测能够有效地反映高血压的进程及患者血管内皮损伤的程度。 　　【关键词】 超敏C反应蛋白；D-二聚体；纤维蛋白原；高血压；血管内皮损伤 　　DOI：10.14163/j.cnki.11-5547/r.2017.01.021 　　Clinical value of high-sensitivity C-reactive protein， D-dimer and fibrinogen in hypertensive vascular endothelial injury ZHANG Kai-ge. Department of Laboratory Medicine， First Affiliated Hospital of Xian Jiaotong University， Xian 710061， China 　　【Abstract】 Objective To investigate clinical application value of high-sensitivity C-reactive protein （hs-CRP）， D-dimer and fibrinogen （FIB） in hypertensive vascular endothelial injury. Methods A total of 86 hypertension patients were divided by their vascular complications into severe group （41 cases） and mild group （45 cases）. There were 40 health people as symptomless group. Detection was made on hs-CRP， D-dimer and FIB levels in all three groups for comparative analysis. Results Patients with hypertension had obviously higher hs-CRP， D-dimer， FIB levels and positive rates than the symptomless group， and their differences all had statistical significance （P0.05）. The severe group had hs-CRP as （9.56±3.15） mg/L， D-dimer as （1.08±0.93） mg/L and FIB as （5.90±2.90） g/L， which were all higher than （5.21±2.30） mg/L， （0.72±0.53） mg/L and （4.80±1.90） g/L in the mild group， and their differences all had statistical significance （P0.05）. The severe group also had higher positive rates of those indexes as 78.0%， 70.7% and 73.2% than 57.8%， 51