选择性肝门阻断联合逆行肝切除巨大肝癌对健侧肝功能保护作用.docVIP

选择性肝门阻断联合逆行肝切除巨大肝癌对健侧肝功能保护作用 　　[摘要] 目的 探讨选择性肝门阻断联合逆行肝切除治疗巨大肝癌对健侧肝组织功能的保护作用。 方法 将2012年3月～2014年2月四川省内江市第二人民医院收治的61例巨大肝癌患者随机分为对照组和观察组，对照组30例患者采用传统肝切除术治疗，观察组31例患者采用选择性肝门阻断联合逆行肝切除治疗，比较两组患者术后健侧肝组织中丙二醛含量、钙离子浓度、超氧化物歧化酶含量、凋亡指数及术后7 d血清前白蛋白、谷丙转氨酶、总胆红素含量。 结果 观察组患者术后丙二醛、钙离子浓度及凋亡指数均显著低于对照组，超氧化物歧化酶含量显著高于对照组，差异均有统计学意义（均P 0.05）。 结论 选择性肝门阻断联合逆行肝切除治疗巨大肝癌能够有效降低患者健侧肝组织缺血再灌注损伤，保护健侧肝脏肝功能。 　　[关键词] 选择性肝门阻断；逆行肝切除；巨大肝癌；健侧肝组织 　　[中图分类号] R735.7 [文献标识码] A [文章编号] 1673-7210（2015）08（a）-0071-03 　　Protective effect of selective hepatic portal occlusion combined with retrograde hepatic resection for uninjured side liver function of huge liver cancer 　　JIANG Huajun1 CHEN Yan2 　　1.Department of General Surgery， the Second Peoples Hospital of Neijiang City， Sichuan Province， Neijiang 641000， China； 2.Department of Surgical Oncology， the Second Peoples Hospital of Neijiang City， Sichuan Province， Neijiang 641000， China 　　[Abstract] Objective To discuss the protective effect of selective hepatic portal occlusion combined with retrograde hepatic resection for uninjured side liver function of huge liver cancer. Methods 61 patients with huge liver cancer in the Second Peoples Hospital of Neijiang City in Sichuan Province from March 2012 to February 2014 were randomly divided into control group （30 cases） with traditional surgery for liver resection and observation group （31 cases） with selective hepatic portal occlusion therapy combined with retrograde liver resection. The levels of MDA content， calcium ion concentration， superoxide dismutase （SOD） content， apoptosis index in the uninjured side of liver tissue， and serum prealbumin （PA）， glutamic pyruvic transaminase and total bilirubin 7 d after operation of both groups were compared. Results The levels of MDA content， calcium ion concentration and apoptosis index of observation group after operation were significant lower than those of the control group （P 0.05）. Conclusion Selective hepatic portal occlusion combined with retrograde hepatic resecti