连续性血液净化治疗脓毒症效果及临床应用优势分析.docVIP

连续性血液净化治疗脓毒症效果及临床应用优势分析 　　[摘要]目的 探讨连续性血液净化治疗脓毒症的效果。方法 选取2012年1月～2015年12月我院收治的100例脓毒症患者作为研究对象，采用随机数字表法分为对照组和观察组，各50例。对照组实施常规治疗，观察组在常规治疗的基础上实施连续性血液净化治疗。比较两组的住院时间、机械通气时间、ICU滞留时间、28 d内死亡率，记录两组治疗前后的急性生理与慢性健康评分（APACHE Ⅱ）及炎症因子指标。结果 观察组的住院时间、机械通气时间、ICU滞留时间显著短于对照组，差异有统计学意义（P0.01）。观察组的死亡率显著低于对照组，差异有统计学意义（P0.05）。两组治疗后的APACHE Ⅱ评分及TNF-α、IL-6、hs-CRP水平显著低于治疗前，差异有统计学意义（P0.01）。观察组治疗后的APACHEⅡ评分及TNF-α、IL-6、hs-CRP水平显著低于对照组，差异有统计学意义（P0.01）。结论 采用连续性血液净化治疗脓毒症患者具有显著的临床效果，可有效缩短患者的治疗时间，降低死亡率，改善患者的急性生理功能和慢性健康状态。 　　[关键词]脓毒症；连续性血液净化；临床应用 　　[中图分类号] R459.5 [文献标识码] A [文章编号] 1674-4721（2016）10（b）-0032-04 　　[Abstract]Objective To explore the efficacy of continuous blood purification in the treatment of sepsis.Methods 100 cases of sepsis from January 2012 to December 2015 in our hospital were selected as the study subject，the patients were divided into the control group and the observation group by using the digital random table method，each group had 50 cases.The control group was given routine treatment，and the observation group was treated with continuous blood purification on the basis of routine treatment.The hospital time，mechanical ventilation time，ICU retention time，28 days mortality was compared between the two groups，and the acute physiology and chronic health evaluation Ⅱ score，the indexes of inflammatory factor before and after treatment were recorded between the two groups.Results The hospital time，mechanical ventilation time，ICU retention time in the observation group was shorter than that in the control group，with significant difference （P0.01）.The mortality in the observation group was lower than that in the control group，with significant difference （P0.05）.The score of APACHE Ⅱ and the level of TNF-α，IL-6，hs-CRP in the two groups after treatment was lower than that before treatment，with significant difference （P0.01）.The score of APACHE Ⅱ and the level of TNF-α，IL-6，hs-CRP in the observation group after treatment was lower than that in the control group，with significant difference