连续性血液滤过对重症胰腺炎患者影响.docVIP

连续性血液滤过对重症胰腺炎患者影响 　　[摘要] 目的 探讨连续性血液净化对重症胰腺炎以及降钙素原的影响情况，为临床治疗重症胰腺炎的方法提供依据。方法 选取2010～2013年就诊于秦皇岛市第二医院的重症胰腺炎患者108例，采用随机数字法将其分为连续性血液净化组及常规治疗组，每组各54例。比较两组的治疗效果，比较分析两组患者的临床症状缓解、住院负担情况以及治疗前后APACHEⅡ评分、降钙素原、血清酶水平。 结果 连续性血液净化组的治愈率为88.89%，明显高于常规治疗组（66.67%），差异有高度统计学意义（P 0.01）。连续性血液净化组住院费用和住院时间方面明显少于常规治疗组，差异有高度统计学意义（P 0.01）；连续性血液净化组腹胀以及腹痛缓解所需时间明显少于常规治疗组，差异有高度统计学意义（P 0.01）。经过多因素多水平的重复资料的方差分析，连续性血液净化组不同时间APACHEⅡ评分比较，差异有高度统计学意义（P 0.01）；治疗后两组降钙素原、血清淀粉酶均明显降低，且连续性血液净化组下降情况明显优于常规治疗组，差异均有统计学意义（P 0.05）。 结论 连续性血液净化对治疗重症胰腺炎，降低降钙素原、血清淀粉酶方面较常规治疗更加经济高效，可提高治愈率，为重症胰腺炎的治疗方法提供一定的依据。 　　[关键词] 重症胰腺炎；连续性血液滤过；降钙素原；疗效 　　[中图分类号] R576 [文献标识码] A [文章编号] 1673-7210（2015）06（c）-0019-04 　　Effect of continuous hemofiltration on patients with severe acute pancreatitis 　　LUO Yuhong1 ZHANG Hui1 ZHANG Xueyan2 TIAN Min2 　　1.Intensive Medicine， the Second Hospital of Qinhuangdao， Hebei Province， Qinhuangdao 066600， China； 2.Endocrinology， Peoples Hospital of Changli County， Hebei Province， Qinhuangdao 066600， China 　　[Abstract] Objective To investigate the effects of continuous blood purification on patients with severe acute pancreatitis and procalcitonin， and provide the basis for clinical treatment of severe acute pancreatitis. Methods 108 patients with severe acute pancreatitis from 2010 to 2013 in the Second Hospital of Qinhuangdao were selected， and according to the random number method， they were divided into continuous blood purification group and conventional treatment group， with 54 cases in each group. The treatment effect of two groups were compared， and clinical symptoms， hospital burden condition and APACHE Ⅱ score， calcitonin， serum enzyme before and after treatment of two groups were analyzed and compared. Results The curative effect the cure rate of the continuous blood purification group was 88.89%， which was significantly higher than that of the conventional treatment group （66.67%）， the difference was statistically significant （P 　　[Key words] Severe acute pancreatitis； Continuous bl