连续性静脉透析滤过CVVHDF治疗危重型流行性出血热临床观察.docVIP

连续性静脉透析滤过CVVHDF治疗危重型流行性出血热临床观察 　　摘要：目的 通过对比危重型流行性出血热患者经腹膜透析或CVVHDF治疗后的临床转归及不良事件发生率，探讨更好的治疗危重型流行性出血热的途径。方法 收集我院2008年12月～2013年5月的危重型流行性出血热行CVVHDF治疗的病例12例，另收集2005年12月～2008年11月的12例危重型流行性出血热的患者并接受腹膜透析的患者的资料，所有患者入院后即给予抗病毒、抗休克、维持水电解质平衡等治疗，达肾功能衰竭期进入透析治疗，对平均透析时间、肾功能部分恢复时间、肾功能完全恢复时间、少尿时间、病死率、平均住院日、平均住院费用及不良事件发生率分别进行比较。结果 ①两组的透析前一般资料无统计学差异。②CVVHDF组在平均透析时间、肾功能部分恢复时间、肾功能完全恢复时间、少尿时间、平均住院日、病死率及不良事件发生率上明显优于腹透组。③在平均住院费用上无统计学差异。结论 CVVHDF的透析方式治疗危重型流行性出血热合并肾功能衰竭优于传统的腹膜透析方式。 　　关键词：CVVHDF；治疗；危重型流行性出血热 　　Abstract：Objective Contrasted clinical outcomes and adverse events during the treatment of the Severe Epidemic Hemorrhagic Fever by Continuous veno-venous Hemodiafiltration （CVVHDF） and Peritoneal dialysis， finding better treatments for the Severe Epidemic Hemorrhagic Fever .Methods Collected 24 cases with Severe Epidemic Hemorrhagic Fever complicated with renal failure in our hospital， 12 cases of them were treated by CVVHDF from 2008.12～2012.5， and others were treated by peritoneal dialysis from 2005.12～2008.11. All cases were received similarly antiviral therapy， anti-shock treatment and maintaining electrolyte balance. Compared the average duration of dialysism， the renal function partial recovery time， the renal function recovery time， the oliguria time， the mortality， average length of inhospital days， the average cost and adverse events between two groups. Results ①The basement of two groups were not difference.②The average duration of dialysis， the renal function partial recovery time， the renal function recovery time， the oliguria time， the mortality， average length of inhospital days and adverse events in the CVVHDF group were significantly decreased compared with the peritoneal dialysis group.③The difference of the average cost between two groups was not significance.Conclusion CVVHDF was better than peritoneal dialysis during the treatment of the Severe Epidemic Hemorrhagic Fever complicated with renal failure. 　　Key words：CVVHDF； Treatment；Severe epidemic hemorrhagic fev