间苯三酚联合黄体酮治疗对先兆流产患者血清孕酮水平及分娩结局影响.docVIP

间苯三酚联合黄体酮治疗对先兆流产患者血清孕酮水平及分娩结局影响 　　摘 要 目的：探讨间苯三酚联合黄体酮治疗对先兆流产患者血清孕酮水平及分娩结局的影响。方法：选取2012年9月―2014年12月期间我院确诊治疗的先兆流产患者120例，依据随机分配原则分为黄体酮组和三酚酮组各60例，黄体酮组患者给予20 mg黄体酮治疗，三酚酮组患者在此基础上给予40 mg间苯三酚治疗，采用新生儿阿氏评分法（Apgar）评估新生儿窒息情况，采用酶联免疫吸附法检测血清孕酮水平，随访至分娩，统计分析所有患者的疗效、治疗前、治疗后1、2、3个月血清孕酮水平、不良反应及分娩结局情况。结果：三酚酮组患者治疗有效率明显高于黄体酮组（P0.05），但所有患者治疗后孕酮水平均明显高于治疗前（P0.05）。结论：间苯三酚联合黄体酮治疗可有效提高先兆流产患者的疗效，改善患者血清孕酮水平，对分娩结局无不良影响，且具有良好的安全性。 　　关键词 间苯三酚 黄体酮 先兆流产 分娩结局 　　中图分类号：R714.21； R975.7 文献标识码：A 文章编号：1006-1533（2016）23-0028-04 　　Effects of phloroglucinol combined with progesterone treatment on serum progesterone levels and birth outcomes of patients with threatened abortion* 　　XIAO Yinghua 　　（Department of Gynecology and Obstetrics， Traditional Chinese Medicine of Jinggangshan City， Jinggangshan 343600， China） 　　ABSTRACT Objective： To discuss the effects of phloroglucinol combined with progesterone therapy on serum progesterone levels and birth outcomes of patients with threatened abortion. Methods： One hundred and twenty patients with threatened abortion， who were treated in our hospital from September， 2012 to December， 2014， were selected and randomly divided into a progesterone group （treated with only progesterone） and a triketophenone group （treated with progesterone plus phloroglucinol） with 60 cases each. Neonatal asphyxia was assessed by neonatal Apgar scoring method and serum progesterone levels were determined by enzyme-linked immunosorbent and follow-up was performed till the delivery. The curative effects， serum progesterone levels before treatment and the first to third months after treatment， adverse reactions and birth outcomes were statistically analyzed. Results： The treatment efficiency was obviously higher in the triketophenone group than in the progesterone group （P0.05）， however， they were higher in all the patients compared with before treatment （P0.05）. Conclusion： Phloroglucinol combined with progesterone therapy can effectively improve the treatment efficacy and serum progest