针刺穴位治疗变应性鼻炎对患者血清IL―2及IFN―γ影响.docVIP

针刺穴位治疗变应性鼻炎对患者血清IL―2及IFN―γ影响 　　【摘要】 目的：探讨针刺穴位治疗变应性鼻炎后鼻腔Th1细胞因子IL-2及IFN-γ的变化。方法：选取变应性鼻炎患者80例，随机分三组，分别进行针刺、鼻腔喷激素、鼻腔喷生理盐水治疗，采用酶联免疫吸附试验（ELISA）检测治疗前后患者血清IL-2及IFN-γ含量的变化。结果：针刺组和鼻腔喷激素患者治疗后IL-2及IFN-γ含量较治疗前均明显增加（P0.05）。针刺组与鼻腔喷激素患者治疗后IL-2及IFN-γ含量比较差异均无统计学意义（P0.05）；针刺组和鼻腔喷激素患者治疗后IL-2及IFN-γ含量与鼻腔喷生理盐水组比较差异均有统计学意义（P0.01）。结论：针刺穴位治疗变应性鼻炎能达到与鼻腔喷激素同样的效果，但能减少鼻腔喷激素引起的副作用，值得推广。 　　【关键词】 针刺穴位； 变应性鼻炎； IL-2； IFN-γ 　　Influence of Acupuncture Treatment of Allergic Rhinitis on Serum IL-2 and IFN-γ/LAN Jian-hua，LUO Xue-mei，ZENG You-gen，et al.//Medical Innovation of China，2016，13（20）：097-099 　　【Abstract】 Objective：To explore changes of nasal Th1 cytokine IL-2 and IFN-γ after acupuncture treatment of allergic rhinitis.Method：A total of 80 patients with allergic rhinitis were randomly divided into three groups，namely acupuncture，steroid nasal spray，saline nasal spray treatment，IL-2 and IFN-γ content of patients before and after treatment were detected by enzyme-linked immunosorbent assay （ELISA）.Result：The in IL-2 and IFN-γ content of the acupuncture group and the steroid nasal spray group after therapy were increased significantly than before treatment（P0.05）.There was no significant difference in the acupuncture group and the steroid nasal spray group with IL-2 and IFN-γ content after treatment（P0.05）.IL-2 and IFN-γ concent of the acupuncture group and the steroid nasal spray group therapy compared with and the saline nasal spray group，the differences were statistically significant（P0.01）.Conclusion：Acupuncture treatment of allergic rhinitis and nasal spray to achieve the same effect as a hormone，but it can reduce the side effects of hormone-induced nasal spray，is worth promoting. 　　【Key words】 Acupuncture points； Allergic rhinitis； IL-2； IFN-γ 　　First-author’s address：The Affiliated Hospital of Jinggangshan University，Ji’an 343000，China 　　doi：10.3969/j.issn.1674-4985.2016.20.026 　　变应性鼻炎是耳鼻咽喉科常见疾病之一，导致变应性性鼻炎的发病机理错综复杂、相互关联，而细胞因子起重要作用。其中Th1/Th2比例失调是导致变应性鼻炎发病的重要机制之一，是目前研究热点[1-4]。本研究通过分子生物学