降钙素原在重症肺炎中临床应用探讨.docVIP

降钙素原在重症肺炎中临床应用探讨 　　[摘要] 目的 探讨对重症肺炎患者使用降钙素原的临床效果。 方法 将2015年10月～2016年10月我院收治的48例重症肺炎患者作为研究组，同期选择48例到我院健康体检者作为对照组。所有患者均使用降钙素原，比较两组降钙素原（PCT）、白细胞计数（WBC）、中性粒细胞百分比、体温及C-反应蛋白（CRP）水平的变化情况，观察降钙素原水平与患者住院时间、抗生素使用频率时间及呼吸机使用次数之间的关系。 结果 两组体温、WBC及中性粒细胞百分比均无显著差异（P0.05），研究组的PCT及CRP水平均高于对照组，差异有统计学意义（P0.05）。研究组患者使用呼吸机次数、抗生素使用时间及住院时间与降钙素原水平之间存在密切关联，差异有统计学意义（P0.05）。 结论 对重症肺炎患者使用降钙素原，不仅能够提高临床诊断的准确率，同时，还能够为后续治疗提供可靠的参考依据。 　　[关键词] 降钙素原；重症肺炎；白细胞计数；C-反应蛋白；临床价值 　　[中图分类号] R563.1 [文献标识码] B [文章编号] 1673-9701（2017）14-0035-03 　　[Abstract] Objective To explore the clinical effect of procalcitonin in patients with severe pneumonia. Methods 48 patients with severe pneumonia treated in our hospital from October 2015 to October 2016 were selected as the study group. 48 healthy subjects in the same period were selected as the control group. All patients were given procalcitonin. The changes of procalcitonin（PCT）， white blood cell count（WBC）， percentage of neutrophils， body temperature and C-reactive protein（CRP） levels between the two groups were compared. The relationship between procalcitonin level and the length of hospital stay， the frequency of antibiotic use， the number of ventilators used was observed. Results There were no significant differences in body temperature， WBC and neutrophil percentage between the two groups（P0.05）. The PCT and CRP levels in the study group were higher than those in the control group，and the differences were statistically significant（P0.05）. There was a significant correlation between the number of ventilators used，the time of antibiotic use， the length of hospital stay and the level of procalcitonin in the study group， and the differences were statistically significant（P0.05）. Conclusion The use of procalcium in patients with severe pneumonia， not only can improve the accuracy of clinical diagnosis， but also can provide a reliable reference for the follow-up treatment. 　　[Key words] Procalcitonin； Severe pneumonia； White blood cell count； C-reactive protein； Clini