人参皂苷Rb1体内外代谢研究进展梁永炎燕茹阮建清王一涛摘要人参.PDFVIP

人參皂苷Rb1 體內外代謝研究進展 梁永炎 燕茹 阮建清 王一濤 摘要 人參屬植物包括人參、西洋參及三七等，在亞洲地區被廣泛用於疾病治療和身體保 健等方面。現代研究表明，以人參皂苷Rb1 為代表的人參皂苷類成分是該類植物的主要生 物活性成分 。Rb1 口服生物利用度低，口服經腸道菌群代謝後主要以其代謝產物的形式吸 收。因此 ，目前對Rb1 的研究主要集中在腸內菌代謝及代謝產物的生物活性上。其中，不 同單一細菌和特異性醣苷酶對Rb1 代謝的途徑及產物是研究的熱點之一。這些研究結果為 深入理解Rb1 體內作用機制和實現工業化生產特定活性代謝物作為藥物及健康產品原料奠 定了理論基礎。本文系統總結了有關Rb1 的代謝研究 ，並簡要介紹了其主要產物的生物活 性。 關鍵詞 ：人參皂苷Rb1 ；代謝；去糖基化；生物活性 Progress in Biotransformation of Ginsenoside Rb1 Weng-Im LEONG, Ru YAN, Jianqing RUAN, Yitao WANG. Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, P. R. China. E-mail: ma76901@umac.mo. Tel: +853- 8397-4880 Abstract Panax species is one of the most popular groups of traditional medicinal herbs that have been used in Asian countries for treatment of diseases and health promotion. Numeous results of modern scientific reseaches indicate that ginsenosides, with Rb1 as one of the major, are the main bioactive components in these herbs. The oral bioavailability of Rb1 is very low. When taken orally, Rb1 is metabolized by intestinal bacteria and mainly absorbed in forms of its metabolites. Therefore, so far, most of the studies focus on intestinal bacterial biotransformation of Rb1 and biological activities of the resultant metabolites. Rb1 metabolic pathway and metabolites generated by individual bacterial strains and specific glucosidases are among the hot topics. The findings from metabolic studies of Rb1 not only shed light on mechanisms behind beneficial effects of Rb1, but also provide valuable information on industrial production of its 1 specific bioactive metabolites as materials for producing drugs and health products in the future. In the present review, the metabolic studies of Rb1 were systematically summarized and biological activities of its major metabolites briefly introduced. Key words: Ginsenoside Rb1; Metabolism; Deglycosylation; Biological activity