卵巢早衰的颗粒细胞凋亡机制研究进展-首都医科大学学报.PDF

2014年 6月摇 摇 摇 摇 摇 首 都 医 科 大 学 学 报 摇 摇 摇 Jun. 2014 第35卷摇 第3期摇 摇 摇 摇 Journal of Capital Medical University Vol郾35摇 No郾3 [doi:10.3969/j.issn.1006鄄7795.2014.03.023] ·综摇 摇 述 · 卵巢早衰的颗粒细胞凋亡机制研究进展 1 2* 2 叶摇 娜 摇 董晓英 摇 李冬华 (1. 首都医科大学基础医学院七年制临床医学专业,北京 100069;2. 首都医科大学中医药学院中医系中医基础教研室, 北京 100069) 揖摘要铱摇 卵巢早衰发病率日益增高,已经成为严重危害女性身心健康的疾病,近年来对其病因的研究很多,目前认为,造成这种 疾病的原因是多方面的,主要有基因缺陷、激素及其受体缺陷、代谢紊乱以及自身免疫失常。 此外,一些人为的机械性损伤,也可 以诱发卵巢早衰,但其确切机制仍未可知。 众多研究显示无论是何原因引起卵巢早衰,都伴有颗粒细胞的凋亡,这也说明了颗粒 细胞的凋亡与卵巢早衰有着直接的关系。 因此,本文就当前关于卵巢早衰中颗粒细胞凋亡的研究进展加以综述,提出卵巢早衰 的细胞凋亡机制,旨在为后续研究提供参考。 揖关键词铱摇 卵巢早衰;细胞凋亡;卵巢颗粒细胞;颗粒细胞;免疫调控 揖中图分类号铱摇 R271.11 The progress in apoptotic mechanism of ovarian granulosa cells involved in premature ovarian failure 1 2* 2 Ye Na ,Dong Xiaoying ,Li Donghua (1. Clinical Medicine of a Seven鄄year Program,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China; 2. Department of Traditional Chinese Medicine,Institute of Traditional Chinese Medicine,Capital Medical University,Beijing 100069, China) 揖Abstract铱摇 Premature ovarian failure(POF),with an increasingly higher and higher incidence,has become a serious disease which threatensfemale health in recent years. Many scholars have studied the etiology of it and found that the cause of this disease is multifaceted:genetic defects,hormone and its receptor defects,metabolic disorders and autoimmune disorders can all account for this disease. In addition,some artificial mechanical damage can also inducePOF,but the exact mechanism is still unknown. No matterwhat cause above is the culprit,apoptosis of the granulosa cells concomitantly is widespread in the study,which shows it showed a direct relationship with POF. In this paper,current research progress of granulosa cellsapoptosis in POFwill